The partial control of dental caries by a well-controlled program of fluoridation of communal water and the health safety of the program has been established. Under support of Grant DEO-1850 we have applied ourselves to answering scientific questions and problems relating to biological processes other than caries that involve fluoride intake. There is need to continue investigations on the general health safety of excessive and deficient amounts of fluoride, and the possibility that beneficial effects other than dental caries reduction may result from optimal intakes. The fluoride intake from all sources (food, liquids, dentrifices, etc.) of individuals of various ages, living in the same and in different dietary regions of the United States will be further investigated. The role of fluoride in bone (resorption, formation and metabolism), lipid metabolism in general, caries prevention and its relation to other trace elements (Zn, Fe, etc.) in metabolism will be elucidated. The primary aim of this proposal is to continue to examine factors which are concerned with the biochemistry, physiology, and nutrition of fluoride. Its concentration, forms, and functions in body fluids, soft tissues, and calcified tissues will also be investigated. Calcified tissue metabolism as well as general metabolic effects will be investigated after long time exposure to high and low fluoride exposure and when specific findings occur that are related to other studies. The general theme of the program will be to investigate fluoride regulation and calcified tissue metabolism. Some of the specific points to be investigated are: (1) Daily fluoride intake of infants and toddlers, (2) interrelation between skeletal fluoride load and plasma fluoride levels, (3) determination of nonionic fluorine in human and non-human serum.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE001850-24
Application #
3094913
Study Section
(SSS)
Project Start
1976-01-01
Project End
1988-12-31
Budget Start
1987-01-01
Budget End
1988-12-31
Support Year
24
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Nopakun, J; Guo, M K; Messer, H H et al. (1988) Fluoride redeposition and retention during bone turnover in lactating rats. J Dent Res 67:1213-6
Guo, M K; Nopakun, J; Messer, H H et al. (1988) Retention of skeletal fluoride during bone turnover in rats. J Nutr 118:362-6
Menczel, J; Singer, L; Ophaug, R H (1987) An investigation of calcium intake, 1-alpha(OH)D3, and etidronate on bone. Bone 8:91-4
Kajander, K C; Uhland, R; Ophaug, R H et al. (1987) Topical fluoride in orthodontic bonding. Angle Orthod 57:70-6
Ophaug, R H; Jenkins, G N; Singer, L et al. (1987) Acid diffusion analysis of different forms of fluoride in human dental plaque. Arch Oral Biol 32:459-61
Ron, M; Singer, L; Menczel, J et al. (1986) Fluoride concentration in amniotic fluid and fetal cord and maternal plasma. Eur J Obstet Gynecol Reprod Biol 21:213-8
Okazaki, M; Ophaug, R H; Singer, L (1985) Promotion of bone dissolution by excessive fluoride in acidic buffer solution. Biomaterials 6:277-80
Singer, L; Ophaug, R H; Harland, B F (1985) Dietary fluoride intake of 15-19-year-old male adults residing in the United States. J Dent Res 64:1302-5
Ophaug, R H; Singer, L; Harland, B F (1985) Dietary fluoride intake of 6-month and 2-year-old children in four dietary regions of the United States. Am J Clin Nutr 42:701-7