Abstract

The common theme of this program project is the regeneration and transplantation of mammalian skeletal muscle. There are four major areas of emphasis in the program: 1) Reintegration of regenerating muscle with the vascular and nervous systems of the host; 2) regulation of genetic expression and protein synthesis in regenerating muscle; 3) devising means of improving the mass of muscle that can be transplanted and improving the functional properties of a given regenerated muscle; 4) in vivo evaluation and prediction of the structure and function of grafted models. Emphasis of component projects is as follows: Daniel Axelrod - dynamics and localization of acetylcholine receptors; Kate Barald - interactions between regenerating muscle and nerve fibers in vitro; Bruce Carlson - interactions between regenerating muscle and nerve in vivo; John Faulkner - revascularization of regenerating muscle; Carl Gans - electromyographic evaluations of the structure and function of regenerating muscle. George Jones - regulation of protein synthesis in regenerating muscle; Jessica Schwartz - hormonal regulation of muscle regeneration; Timothy White - effects of physical conditioning on regenerating muscle.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE007687-05
Application #
3094982
Study Section
Neurological Disorders Program Project Review B Committee (NSPB)
Project Start
1981-09-01
Project End
1990-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Borisov, A B; Carlson, B M (2000) Cell death in denervated skeletal muscle is distinct from classical apoptosis. Anat Rec 258:305-18
Kasper, C E (1999) Recovery of plantaris muscle from impaired physical mobility. Biol Res Nurs 1:4-11
Kasper, C E; Maxwell, L C; White, T P (1996) Alterations in skeletal muscle related to short-term impaired physical mobility. Res Nurs Health 19:133-42
Miller, S W; Opiteck, J A; White, T P et al. (1996) Functional evaluation at the medial gastrocnemius donor site in rats. J Reconstr Microsurg 12:143-7
Devor, S T; White, T P (1996) Myosin heavy chain of immature soleus muscle grafts adapts to hyperthyroidism more than to physical activity. J Appl Physiol 80:789-94
Esser, K A; White, T P (1995) Mechanical load affects growth and maturation of skeletal muscle grafts. J Appl Physiol 78:30-7
Devor, S T; White, T P (1995) Myosin heavy chain phenotype in regenerating skeletal muscle is affected by thyroid hormone. Med Sci Sports Exerc 27:674-81
Miller, S W; Hassett, C A; White, T P et al. (1994) Recovery of medial gastrocnemius muscle grafts in rats: implications for the plantar flexor group. J Appl Physiol 77:2773-7
Stevenson, T R; Kadhiresan, V A; Faulkner, J A (1994) Tubular nerve guide and epineurial repair: comparison of techniques for neurorrhaphy. J Reconstr Microsurg 10:171-4
White, T P; Devor, S T (1993) Skeletal muscle regeneration and plasticity of grafts. Exerc Sport Sci Rev 21:263-95

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