The proposed research program consists of 6 closely related interdisciplinary projects which focus on one or more aspects of the dilemma between nutritional goals and metabolic tolerance of low birth weight infants. Project A addresses questions concerning growth as well as biochemical evidence of protein sufficiency or excess incident to feeding either human milk or artificial formulas differing in protein and energy content. Questions concerning the effects of these diets on immunological development are addressed in Project B. Other projects focus on differences in body ccmposition (Project C) as well as energy expenditure (Project D) incident to the various diets. In these projects, relationships between anthropometric variables and measured body composition as well as relationships between measured body composition and that predicted from studies of energy balance will be identified. Project B explores questions related to metabolism of intravenously administered amino acids in an effort to design a mixture of amino acids which will result in a completely normal plasma amino acid pattern. The final project includes in vitro studies addressing a number of questions concerning theoretical immunological hazards or benefits related to the cellular components of human milk. A human milk bank is proposed both to provide a safe source of milk for infants enrolled in the various projects and to provide basic practical information concerning various aspects of milk banking. The program also includes biomathematical and administrative support components. In total, this program will provide new information concerning possible benefits and drawbacks in feeding low birth weight infants with human milk. It will also provide much needed data for the overall improvement of nutritional management of these infants.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD013020-07
Application #
3096724
Study Section
Maternal and Child Health Research Committee (HDMC)
Project Start
1980-08-01
Project End
1989-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
7
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
de Klerk, A; Schulze, K F; Kashyap, S et al. (1997) Diet and infant behavior. Acta Paediatr Suppl 422:65-8
Towers, H M; Schulze, K F; Ramakrishnan, R et al. (1997) Energy expended by low birth weight infants in the deposition of protein and fat. Pediatr Res 41:584-9
Kashyap, S; Schulze, K F; Ramakrishnan, R et al. (1994) Evaluation of a mathematical model for predicting the relationship between protein and energy intakes of low-birth-weight infants and the rate and composition of weight gain. Pediatr Res 35:704-12
Schulze, K; Kashyap, S; Ramakrishnan, R (1993) Cardiorespiratory costs of growth in low birth weight infants. J Dev Physiol 19:85-90
Isaacs, C E; Kashyap, S; Heird, W C et al. (1990) Antiviral and antibacterial lipids in human milk and infant formula feeds. Arch Dis Child 65:861-4
Kashyap, S; Schulze, K F; Forsyth, M et al. (1990) Growth, nutrient retention, and metabolic response of low-birth-weight infants fed supplemented and unsupplemented preterm human milk. Am J Clin Nutr 52:254-62
Heird, W C; Kashyap, S (1989) Protein and energy requirements of low birth weight infants. Acta Paediatr Scand Suppl 351:13-23
Kashyap, S; Schulze, K F; Forsyth, M et al. (1988) Growth, nutrient retention, and metabolic response in low birth weight infants fed varying intakes of protein and energy. J Pediatr 113:713-21
Kashyap, S; Okamoto, E; Kanaya, S et al. (1987) Protein quality in feeding low birth weight infants: a comparison of whey-predominant versus casein-predominant formulas. Pediatrics 79:748-55
Brennan, J; Schulze, K; James, L S (1986) A microcomputer system for monitoring ventilation in neonates. Int J Clin Monit Comput 3:11-6

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