Preeclampsia is a major contributor to maternal and perinatal morbidity and mortality. Prevention andtreatment require an understanding of both pathophysiology and clinical characterization. The Data andClinical Core centralizes participant recruitment, data collection, data management, protocol implementationfor clinically related projects within the Program Project. Specifically, these activities will entail recruiting,over a four-year period, an estimated 600 overweight (based upon pre-pregnancy measures) and 100normal weighted nulliparous pregnant women without prior evidence of preexisting hypertension and withsingleton gestations from Magee-Womens Hospital in Pittsburgh. Baseline clinical data will be obtainedbetween 10 and 15 weeks gestation and additional biological specimens will be collected throughout thepregnancy. Approximately 100 of the recruited participants will be cross-enrolled in a randomized controlledclinical trial comparing L-arginine and placebo for 3 weeks beginning at 14 -16 weeks of gestation forintermediate outcomes in support of Projects II, III, and IV (Roberts, Hubel, and Gandley). Furthermore, 25obese women with severe preeclampsia and 25 lean women with severe preeclampsia will be studied crosssectionallyat labor and delivery (for Projects II, III, and IV). Women undergoing Caesarian- sectiondeliveries will be recruited for collection of adipose tissue and placental samples (for Project IV, Gandley).The Clinical Data Core staff will be responsible for participant recruitment, data collection, and qualityassurance. The Core will also characterize women with preeclampsia using a strict set of diagnostic criteriaand a jury of clinical experts. Data will be organized and maintained using the expertise within the Center forResearch on Health Care, Data Center.The Core will continue to build on current success. To date, in the Program Project, we have enrolled over4000 women and have identified almost 900 preeclamptic women. We are confident in our abilities tocontinue successful recruitment of participants and maintaining quality data to support clinical projects in theProgram Project.
| Global Pregnancy Collaboration:; Schalekamp-Timmermans, Sarah; Arends, Lidia R et al. (2017) Fetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis. Int J Epidemiol 46:632-642 |
| Hux, Vanessa J; Roberts, James M; Okun, Michele L (2017) Allostatic load in early pregnancy is associated with poor sleep quality. Sleep Med 33:85-90 |
| Countouris, Malamo E; Schwarz, Eleanor B; Rossiter, Brianna C et al. (2016) Effects of lactation on postpartum blood pressure among women with gestational hypertension and preeclampsia. Am J Obstet Gynecol 215:241.e1-8 |
| Gandley, Robin E; Althouse, Andrew; Jeyabalan, Arundhathi et al. (2016) Low Soluble Syndecan-1 Precedes Preeclampsia. PLoS One 11:e0157608 |
| Schmella, Mandy J; Ferrell, Robert E; Gallaher, Marcia J et al. (2015) The -93T/G LPL Promoter Polymorphism Is Associated With Lower Third-Trimester Triglycerides in Pregnant African American Women. Biol Res Nurs 17:429-37 |
| Founds, Sandra; Zeng, Xuemei; Lykins, David et al. (2015) Developing Potential Candidates of Preclinical Preeclampsia. Int J Mol Sci 16:27208-27 |
| Tan, Hong Chang; Roberts, James; Catov, Janet et al. (2015) Mother's pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood. Pediatr Diabetes 16:419-26 |
| Schmella, Mandy J; Clifton, Rebecca G; Althouse, Andrew D et al. (2015) Uric Acid Determination in Gestational Hypertension: Is it as Effective a Delineator of Risk as Proteinuria in High-Risk Women? Reprod Sci 22:1212-9 |
| Luiza, John W; Gallaher, Marcia J; Powers, Robert W (2015) Urinary cortisol and depression in early pregnancy: role of adiposity and race. BMC Pregnancy Childbirth 15:30 |
| Hux, Vanessa J; Roberts, James M (2015) A potential role for allostatic load in preeclampsia. Matern Child Health J 19:591-7 |
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