Abstract

This project develops new labeling techniques generally applicable to the positron emitting radionuclides carbon-11 of fluorine-18. In the current proposal several areas are emphasized. These areas are: 1. The synthesis and evaluation of fatty acids labeled in 3 specific positions. 2. The evaluation of a new hypoxic imaging agent. 3. The development of new labeling agents involving carbon-11 labeled hypofluorite as a new synthon and new approaches to protein and peptide labeling of compounds with potential medical application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL013851-38
Application #
6467589
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Peterson, Linda R; Herrero, Pilar; Coggan, Andrew R et al. (2015) Type 2 diabetes, obesity, and sex difference affect the fate of glucose in the human heart. Am J Physiol Heart Circ Physiol 308:H1510-6
Zhou, Dong; Chu, Wenhua; Xu, Jinbin et al. (2014) Synthesis, [¹?F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem 22:1700-7
Gropler, Robert J (2014) Trying to prevent diabetic cardiovascular autonomic neuropathy: more questions than answers. J Nucl Cardiol 21:842-4
Lyons, Matthew R; Peterson, Linda R; McGill, Janet B et al. (2013) Impact of sex on the heart's metabolic and functional responses to diabetic therapies. Am J Physiol Heart Circ Physiol 305:H1584-91
Solingapuram Sai, Kiran Kumar; Kil, Kun-Eek; Tu, Zhude et al. (2012) Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-? receptors. Bioorg Med Chem Lett 22:6233-6
Cheng, Ju-Chieh Kevin; Shoghi, Kooresh; Laforest, Richard (2012) Quantitative accuracy of MAP reconstruction for dynamic PET imaging in small animals. Med Phys 39:1029-41
Peterson, Linda R; Saeed, Ibrahim M; McGill, Janet B et al. (2012) Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans. Obesity (Silver Spring) 20:802-10
Zhou, Dong; Chu, Wenhua; Dence, Carmen S et al. (2012) Highly efficient click labeling using 2-[¹?F]fluoroethyl azide and synthesis of an ¹?FN-hydroxysuccinimide ester as conjugation agent. Nucl Med Biol 39:1175-81
Chen, Delphine L; Zhou, Dong; Chu, Wenhua et al. (2012) Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nucl Med Biol 39:137-44
Lee, Hsiaoju; Chen, Delphine L; Rothfuss, Justin M et al. (2012) Synthesis and evaluation of 18F-labeled PPAR? antagonists. Nucl Med Biol 39:77-87

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