The main aim of this project is to study the role of the autonomic nervous system in the regulation of energy metabolism and its possible contribution to the pathophysiology of obesity and type 2 diabetes. We use microneurography to measure muscle sympathetic nerve activity (MSNA) and plasma/urine catecholamines to measure global sympathetic nervous system (SNS) activity. We use fasting and post-prandial pancreatic polypeptide, pupillometry, heart rate/blood pressure tests, and gastric emptying rate to assess parasympathetic nervous system (PNS) activity. In the past year we have: a) completed a collaborative study to assess possible differences in 11-beta-HSD activity, a tissue specific modulator of cortisol sensitivity, in Pimas and Caucasians (data being currently analyzed); b) continued a study on the role of PNS in insulin secretory function in Pimas and Caucasians (ongoing); c) continued a study on the SNS response to a standard meal in Pimas and Caucasians (ongoing)

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK069077-03
Application #
6673903
Study Section
(PECR)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code