Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL040453-04
Application #
3098664
Study Section
Heart, Lung, and Blood Research Review Committee B (HLBB)
Project Start
1988-09-01
Project End
1993-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Kavanaugh, J S; Chafin, D R; Arnone, A et al. (1995) Structure and oxygen affinity of crystalline desArg141 alpha human hemoglobin A in the T state. J Mol Biol 248:136-50
Kelly, R M; Hui, H L; Noble, R W (1994) Chloride acts as a novel negative heterotropic effector of hemoglobin Rothschild (beta 37 Trp-->Arg) in solution. Biochemistry 33:4363-7
Borgstahl, G E; Rogers, P H; Arnone, A (1994) The 1.9 A structure of deoxy beta 4 hemoglobin. Analysis of the partitioning of quaternary-associated and ligand-induced changes in tertiary structure. J Mol Biol 236:831-43
Fowler, S A; Andracki, M; Hurst, G et al. (1994) Prolongation of the intravascular retention of hemoglobin modified with a long-chain fatty acid derivative. Artif Cells Blood Substit Immobil Biotechnol 22:27-42
Borgstahl, G E; Rogers, P H; Arnone, A (1994) The 1.8 A structure of carbonmonoxy-beta 4 hemoglobin. Analysis of a homotetramer with the R quaternary structure of liganded alpha 2 beta 2 hemoglobin. J Mol Biol 236:817-30
Kwiatkowski, L D; De Young, A; Noble, R W (1994) Isolation and stability of partially oxidized intermediates of carp hemoglobin: kinetics of CO binding to the mono- and triferric species. Biochemistry 33:5884-93
Bashford, D; Case, D A; Dalvit, C et al. (1993) Electrostatic calculations of side-chain pK(a) values in myoglobin and comparison with NMR data for histidines. Biochemistry 32:8045-56
Kwiatkowski, L D; Noble, R W (1993) The effect of 75% glycerol on the oxygen binding properties of carp hemoglobin. Biochem Biophys Res Commun 195:1218-23
Kavanaugh, J S; Moo-Penn, W F; Arnone, A (1993) Accommodation of insertions in helices: the mutation in hemoglobin Catonsville (Pro 37 alpha-Glu-Thr 38 alpha) generates a 3(10)-->alpha bulge. Biochemistry 32:2509-13
Rivetti, C; Mozzarelli, A; Rossi, G L et al. (1993) Effect of chloride on oxygen binding to crystals of hemoglobin Rothschild (beta 37 Trp-->Arg) in the T quaternary structure. Biochemistry 32:6411-8

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