Abstract

to Dr. van Breemen by the manufacturer to support the development of ultrafiltration mass spectrometry as a tool for drug discovery and development. To prevent delays when demands for the QTOF2 become great, this instrument may be used to support peptide sequencing and characterization as well. Micromass Quattro II triple quadrupole mass spectrometer. Installed during 1997 and purchased with an NIH shared instrument grant (P.I. Dr. van Breemen), this triple quadrupole mass spectrometer is equipped with a Water 2690 analytical HPLC system, electrospray ionization, atmospheric pressure chemical ionization (APCI), and MS-MS with CID. It is used primarily for structural analysis of natural products and drug metabolites or for quantitative analysis of therapeutic agents and drug metabolites. Thermo Electron (Finnigan) TSQ Quantum triple quadrupole mass spectrometer. Purchased in 2002 to help with the backlog of samples awaiting quantitative analysis using LC-MS-MS, this instrument is equipped with a Surveyor analytical HPLC system, 282

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062426-09
Application #
7633303
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
9
Fiscal Year
2008
Total Cost
$255,280
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Dvornikov, Alexey V; de Tombe, Pieter P; Xu, Xiaolei (2018) Phenotyping cardiomyopathy in adult zebrafish. Prog Biophys Mol Biol 138:116-125
Le, Long V; Mohindra, Priya; Fang, Qizhi et al. (2018) Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction. Biomaterials 169:11-21
Mkrtschjan, Michael A; Gaikwad, Snehal B; Kappenman, Kevin J et al. (2018) Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography. J Cell Physiol 233:3672-3683
Yan, Jiajie; Thomson, Justin K; Zhao, Weiwei et al. (2018) Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia. J Am Coll Cardiol 71:1459-1470
Bohlooli Ghashghaee, Nazanin; Li, King-Lun; Solaro, R John et al. (2018) Role of the C-terminus mobile domain of cardiac troponin I in the regulation of thin filament activation in skinned papillary muscle strips. Arch Biochem Biophys 648:27-35
Yan, Jiajie; Zhao, Weiwei; Thomson, Justin K et al. (2018) Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res 122:821-835
Ait Mou, Younss; Lacampagne, Alain; Irving, Thomas et al. (2018) Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy. J Mol Cell Cardiol 114:345-353
Ferrantini, Cecilia; Coppini, Raffaele; Pioner, Josè Manuel et al. (2017) Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models. J Am Heart Assoc 6:
Alves, Marco L; Warren, Chad M; Simon, Jillian N et al. (2017) Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice. Cardiovasc Res 113:915-925
Zak, Taylor J; Koshman, Yevgenia E; Samarel, Allen M et al. (2017) Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor. Biochemistry 56:4722-4731

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