Academic and marital stress appear to modulate immunologic function. It is attractive to consider that stress related hormonal secretion could mediate these effects. Although surgical and exercise stress have been well documented to increase hormone secretion the role of psychological stress on pituitary-adrenal hormone release is not clear. Previous studies have examined only a few hormones in subjects at infrequent intervals and the conclusions have been contradictory. Therefore we propose to measure by radioimmunoassay and HPLC all of the candidate """"""""stress"""""""" related hormones, (ACTH, cortisol, growth hormone, prolactin, catecholamines and B-endorphin) in blood samples acquired in sub- jects during the stress of preparing for major medical examinations or during a stressful marriage interactive protocol. Hourly sampling over a 24 hr period in the Clinical Research Center will be performed periodically in both stressed groups of subjects. This 24 hr analysis will permit an evaluation of both day and nocturnal hormonal release. Immunologic, psychologic, and health testing will be performed at the same time. Hence, in this in- vestigation we will provide a comprehensive endocrine evaluation of pituitary and adrenal hormonal secretion that may be influenced by academic and marital stress. This study will fill a gap in the literature by providing a simultaneous evaluation of all the candidate stress hormones in individuals experiencing commonly encountered stressors. Finally we will be able to assess the potential impact of disordered hormonal secretion on the immune system and health status of stressed individuals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH044660-03
Application #
3881512
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Jaremka, Lisa M; Glaser, Ronald; Malarkey, William B et al. (2013) Marital distress prospectively predicts poorer cellular immune function. Psychoneuroendocrinology 38:2713-9
Heffner, Kathi L; Kiecolt-Glaser, Janice K; Loving, Timothy J et al. (2004) Spousal support satisfaction as a modifier of physiological responses to marital conflict in younger and older couples. J Behav Med 27:233-54
Kiecolt-Glaser, Janice K; Bane, Cynthia; Glaser, Ronald et al. (2003) Love, marriage, and divorce: newlyweds' stress hormones foreshadow relationship changes. J Consult Clin Psychol 71:176-88
Cacioppo, John T; Kiecolt-Glaser, Janice K; Malarkey, William B et al. (2002) Autonomic and glucocorticoid associations with the steady-state expression of latent Epstein-Barr virus. Horm Behav 42:32-41
Glaser, R; Friedman, S B; Smyth, J et al. (1999) The differential impact of training stress and final examination stress on herpesvirus latency at the United States Military Academy at West Point. Brain Behav Immun 13:240-51
Glaser, R; Kiecolt-Glaser, J K; Malarkey, W B et al. (1998) The influence of psychological stress on the immune response to vaccines. Ann N Y Acad Sci 840:649-55
Kiecolt-Glaser, J K; Glaser, R; Cacioppo, J T et al. (1998) Marital stress: immunologic, neuroendocrine, and autonomic correlates. Ann N Y Acad Sci 840:656-63
Kiecolt-Glaser, J K; Glaser, R; Cacioppo, J T et al. (1997) Marital conflict in older adults: endocrinological and immunological correlates. Psychosom Med 59:339-49
Wu, H; Devi, R; Malarkey, W B (1996) Localization of growth hormone messenger ribonucleic acid in the human immune system--a Clinical Research Center study. J Clin Endocrinol Metab 81:1278-82
Wu, H; Devi, R; Malarkey, W B (1996) Expression and localization of prolactin messenger ribonucleic acid in the human immune system. Endocrinology 137:349-53

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