Chronic pain is a major source of human suffering and a major economic problem in American society. Because the problem has long gone unrecognized, there has been little research on which to base improvements in pain patient management. This application requests support to continue our multidisciplinary research program on chronic pain. We propose to carry out seven interrelated research projects involving varying disciplines that will shed light on the mechanisms of pain, the development of pain chronicity, the clinical manifestations of chronic pain, and the treatment of chronic pain. These consist of two studies to be done on the Clinical Pain Service, an additional study of chronic pain patients, and four laboratory investigations. Two of these will employ animal physiology, the third is an animal pharmacology project, and the fourth will investigate chronic pain patients in a human subjects laboratory. In order to accomplish this we will establish a multidisciplinary network of scientific interchange, collaboration, and resource sharing that enhances and expedites the work done under each of the individual projects. Interchange among project leaders will be both formal and informal including monthly project seminars and semi-annual consultation visits by outside scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS016329-06
Application #
3099578
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1980-09-30
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1987-08-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Turner, J A; Jensen, M P (1993) Efficacy of cognitive therapy for chronic low back pain. Pain 52:169-77
Turner, J A; Clancy, S; McQuade, K J et al. (1990) Effectiveness of behavioral therapy for chronic low back pain: a component analysis. J Consult Clin Psychol 58:573-9
Romano, J M; Turner, J A; Clancy, S L (1989) Sex differences in the relationship of pain patient dysfunction to spouse adjustment. Pain 39:289-95
Kawakami, Y; Suzuki, H; Dong, W K (1989) Assessment of peripheral nerve crush injury with cortical somatosensory evoked potentials in the cat. Exp Neurol 103:146-53
Turner, J A; Clancy, S (1988) Comparison of operant behavioral and cognitive-behavioral group treatment for chronic low back pain. J Consult Clin Psychol 56:261-6
Burchiel, K J; Clarke, H; Haglund, M et al. (1988) Long-term efficacy of microvascular decompression in trigeminal neuralgia. J Neurosurg 69:35-8
McQuade, K J; Turner, J A; Buchner, D M (1988) Physical fitness and chronic low back pain. An analysis of the relationships among fitness, functional limitations, and depression. Clin Orthop Relat Res :198-204
Burchiel, K J (1988) Percutaneous retrogasserian glycerol rhizolysis in the management of trigeminal neuralgia. J Neurosurg 69:361-6
Turner, J A; Clancy, S; Vitaliano, P P (1987) Relationships of stress, appraisal and coping, to chronic low back pain. Behav Res Ther 25:281-8
Halpern, L M; Dong, W K (1986) D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model. Pain 24:223-37

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