Abstract

This proposal is for multidisciplinary AIDS-Encephalopathy program project. It will focus on the immunological and molecular aspects of the AIDS- Dementia Complex. The project will involve investigators from the departments of Neurology, Medicine, Pediatrics, Pathology, and Microbiology at USC and the Childrens Hospital of Los Angeles. The 5 projects and 2 supporting Cores of morphologic assessment and modern immunological and molecular biological methodology to study AIDS-Dementia. Project 1 will study the role of the T lymphocyte in CNS HIV infection. Project 2 is a study of the molecular basis of HIV-1 gene control and examine HIV-1 tat gene expression in the developing nervous system of transgenic animals. Project 3 will study protein biosynthesis in different cell types which may be involved in AIDS-dementia. Project 4 will be focused on designing novel protein molecules to be used as vaccines to prevent and combat asymptomatic CNS infections. Project 5 will the use of retroviral vectors to express HIV antisense RNA in the CNS marrow transplantation delivery of stem cells. The Support and Pathology Core; in addition to its regular functions, will contain an HIV-1 Safety and Inactivation Committee. The Microchemical Core will provide unique peptides and sequencing. In summary, this program will apply modern techniques to the study of the pathogenesis of the AIDS-Dementia Complex.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS026991-02
Application #
3100274
Study Section
Neurological Disorders Program Project Review B Committee (NSPB)
Project Start
1990-01-01
Project End
1994-12-31
Budget Start
1991-01-01
Budget End
1991-12-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Kundu, R K; Sangiorgi, F; Wu, L Y et al. (1999) Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma. Blood 94:275-82
Villacres, M C; Bergmann, C C (1999) Enhanced cytotoxic T cell activity in IL-4-deficient mice. J Immunol 162:2663-70
Williams-Hill, D M; Duncan, R F; Nielsen, P J et al. (1997) Differential expression of the murine eukaryotic translation initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon cellular growth status. Arch Biochem Biophys 338:111-20
Bergmann, C C; Yao, Q; Ho, C K et al. (1996) Flanking residues alter antigenicity and immunogenicity of multi-unit CTL epitopes. J Immunol 157:3242-9
Sippy, B D; Hofman, F M; Wallach, D et al. (1995) Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 10:511-21
Krall, W J; Challita, P M; Perlmutter, L S et al. (1994) Cells expressing human glucocerebrosidase from a retroviral vector repopulate macrophages and central nervous system microglia after murine bone marrow transplantation. Blood 83:2737-48
Tahara, S M; Dietlin, T A; Bergmann, C C et al. (1994) Coronavirus translational regulation: leader affects mRNA efficiency. Virology 202:621-30
Zhou, C; Bahner, I C; Larson, G P et al. (1994) Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene 149:33-9
Bergmann, C C; Tong, L; Cua, R V et al. (1994) Cytotoxic T cell repertoire selection. A single amino acid determines alternative class I restriction. J Immunol 152:5603-12
Kureshi, S A; Hofman, F M; Schneider, J H et al. (1994) Cytokine expression in radiation-induced delayed cerebral injury. Neurosurgery 35:822-9;discussion 829-30

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