Morphometric Neuroimaging

Caviness, Vern

Abstract

Morphometric analysis of MR scans will be undertaken to provide descriptions of the location and size of lesions in 100 patients studied in projects 1 - 3. Scans will be obtained with FAST-imaging volumetric T1-weighted imaging. Each brain will be segmented into principal gray and white matter structures and lesioned areas. The neocortex will be parcellated according to a method based upon limiting fissures which is referenced to the Brodman (1909) architectonic map and is thus compatible with Mesulain's (1985) scheme of neural hierarchy. Lesions will be subdivided into levels that correspond to damage to remote fiber systems (Level I), local fiber systems (Level II), and cortex itself (Level III). Volumetric computations will be applied to segmented structures, including parcellation units of cortex and levels of lesion. Data analysis will be based upon investigator-interactive, computer-assisted, semi-automated image reformatting and segmentation algorithms that are already operational and that will be made more efficient. Correlations between lesion location and size and cognitive deficits described in projects 1 - 3 will be established through planned comparisons and regression analyses.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Program Projects (P01)
• Project #: 5P01NS027950-04
• Application #: 5215312
• Support Year: 4
• Fiscal Year: 1996

Publications

Makris, N; Kennedy, D N; Boriel, D L et al. (2010) Methods of MRI-based structural imaging in the aging monkey. Methods 50:166-77

Kennedy, David N; Haselgrove, Christian; Makris, Nikos et al. (2010) WebParc: a tool for analysis of the topography and volume of stroke from MRI. Med Biol Eng Comput 48:215-28

Makris, Nikos; Caviness, Verne S; Kennedy, David N (2005) An introduction to MR imaging-based stroke morphometry. Neuroimaging Clin N Am 15:325-39, x

Herbert, M R; Ziegler, D A; Deutsch, C K et al. (2005) Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain 128:213-26

Herbert, Martha R; Ziegler, David A; Makris, Nikos et al. (2004) Localization of white matter volume increase in autism and developmental language disorder. Ann Neurol 55:530-40

Herbert, M R; Ziegler, D A; Deutsch, C K et al. (2003) Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 126:1182-92

Caviness, V S; Makris, N; Montinaro, E et al. (2002) Anatomy of stroke, Part II: volumetric characteristics with implications for the local architecture of the cerebral perfusion system. Stroke 33:2557-64

Caviness, V S; Makris, N; Montinaro, E et al. (2002) Anatomy of stroke, Part I: an MRI-based topographic and volumetric System of analysis. Stroke 33:2549-56

Caviness Jr, V S; Makris, N; Lange, N T et al. (2000) Advanced applications of MRI in human brain science. Keio J Med 49:66-73

Curran, T; Schacter, D L; Galluccio, L (1999) Cross-modal priming and explicit memory in patients with verbal production deficits. Brain Cogn 39:133-46