Abstract

The Scientific Core is designed to provide an organization structure for scientific efforts common to all projects within the program. Specifically, the Scientific Core will provide 5% support for the Program Director. The Program Director meets with the Clinical Coordinator on a daily basis to prioritize scientific efforts on all human and monkey specimens received, and meets with the DNA Sequencer no less than twice weekly to coordinate sequencing priorities, plan strategies and evaluate data. The Scientific Core will provide 100% support for the Clinical Coordinator whose efforts are devoted to acquiring, banking and computerizing all tissue from humans and monkeys. The Scientific Core will also provide 100% support for a DNA sequencer whose expertise in DNA sequencing and analysis is required for all three projects. In addition, the Scientific Core will provide support for external consultants necessary for scientific evaluation for scientific evaluation of the Program Project every year. Finally, the Scientific Core will provide support for common use equipment and service contracts.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
3P01NS032623-12S1
Application #
6346298
Study Section
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
2000
Total Cost
$242,910
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Cohrs, Randall J; Lee, Katherine S; Beach, Addilynn et al. (2017) Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion. J Virol 91:
Ouwendijk, Werner J D; van Veen, Suzanne; Mahalingam, Ravi et al. (2017) Simian varicella virus inhibits the interferon gamma signalling pathway. J Gen Virol :
Ouwendijk, Werner J D; Getu, Sarah; Mahalingam, Ravi et al. (2016) Characterization of the immune response in ganglia after primary simian varicella virus infection. J Neurovirol 22:376-88
Birlea, Marius; Owens, Gregory P; Eshleman, Emily M et al. (2013) Human anti-varicella-zoster virus (VZV) recombinant monoclonal antibody produced after Zostavax immunization recognizes the gH/gL complex and neutralizes VZV infection. J Virol 87:415-21
Mueller, Niklaus H; Bos, Nathan L; Seitz, Scott et al. (2012) Recombinant monoclonal antibody recognizes a unique epitope on varicella-zoster virus immediate-early 63 protein. J Virol 86:6345-9
Nagel, Maria A; Bert, Robert J; Gilden, Don (2012) Raeder syndrome produced by extension of chronic inflammation to the internal carotid artery. Neurology 79:1296-7
Wolf, James; Nagel, Maria A; Mahalingam, Ravi et al. (2012) Chronic active varicella zoster virus infection. Neurology 79:828-9
Brennan, Kathryn M; Galban-Horcajo, Francesc; Rinaldi, Simon et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. J Neuroimmunol 238:87-95
Azarkh, Yevgeniy; Gilden, Don; Cohrs, Randall J (2010) Molecular characterization of varicella zoster virus in latently infected human ganglia: physical state and abundance of VZV DNA, Quantitation of viral transcripts and detection of VZV-specific proteins. Curr Top Microbiol Immunol 342:229-41
Sargsyan, S A; Shearer, A J; Ritchie, A M et al. (2010) Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis. Neurology 74:1127-35

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