Abstract

Regional adiposity, specifically localization of an increased proportion of body fat in the abdominal region, is an independent risk factor for myocardial infarction, angina pectoris, stroke, noninsulin-dependent diabetes mellitus (NIDDM), and premature death. While causal mechanisms for these relationships have not been identified, excess abdominal fat has been associated with several of the risk factors for both cardiovascular disease and NIDDM, namely dyslipidemia, hyperinsulinemia, and glucose intolerance. Hormone replacement therapy has been found to prevent the accumulation of intra-abdominal fat observed in postmenopausal women. Although data are scarce, this and other observations support the theory that sex steroids affect the regulation of fat accumulation, mobilization, and distribution. The objectives of this project are: to evaluate the effects of hormone replacement therapy on regional fat distribution and characteristics; and to examine the relationships between fat distribution, risk factors for NIDDM and cardiovascular disease, and extent of coronary artery atherosclerosis in a well-characterized primate model, the female cynomolgus monkey.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Program Projects (P01)
Project #
5P01RR008562-02
Application #
3767364
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106

  Publications

Di Cesare, P E; Fang, C; Leslie, M P et al. (1999) Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage. J Orthop Res 17:437-45
Anderson, J J; Anthony, M S; Cline, J M et al. (1999) Health potential of soy isoflavones for menopausal women. Public Health Nutr 2:489-504
Ekman, S; Carlson, C S (1998) The pathophysiology of osteochondrosis. Vet Clin North Am Small Anim Pract 28:17-32
Tansey, G; Hughes Jr, C L; Cline, J M et al. (1998) Effects of dietary soybean estrogens on the reproductive tract in female rats. Proc Soc Exp Biol Med 217:340-4
Di Cesare, P E; Carlson, C S; Attur, M et al. (1998) Up-regulation of inducible nitric oxide synthase and production of nitric oxide by the Swarm rat and human chondrosarcoma. J Orthop Res 16:667-74
Obasanjo, I O; Cline, J M; Schmotzer, S et al. (1998) Nandrolone decanoate causes pathologic changes in the uterus of surgically postmenopausal female cynomolgus macaques. Menopause 5:163-8
Cline, J M; Hughes Jr, C L (1998) Phytochemicals for the prevention of breast and endometrial cancer. Cancer Treat Res 94:107-34
Foth, D; Cline, J M (1998) Effects of mammalian and plant estrogens on mammary glands and uteri of macaques. Am J Clin Nutr 68:1413S-1417S
O'Sullivan, M G; Anderson, D K; Goodrich, J A et al. (1997) Experimental infection of cynomolgus monkeys with simian parvovirus. J Virol 71:4517-21
Clarkson, T B; Cline, J M; Williams, J K et al. (1997) Gonadal hormone substitutes: effects on the cardiovascular system. Osteoporos Int 7 Suppl 1:S43-51

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