Abstract

) The goal of the Colorado Program in Aging and Cancer is to develop a new program in aging and cancer at the University of Colorado Comprehensive Cancer Center that will foster inter-disciplinary and inter-institutional research in cancer and aging in Colorado and the Rocky Mountain Region. The Colorado Program in Aging and Cancer is designed to be complementary with other successful Programs at the University of Colorado Comprehensive Cancer Center and with the successful clinical, educational, and research programs in geriatrics and oncology within the Division of Geriatric Medicine and the University of Colorado Center on Aging. The Program will feature education both within the Cancer Center and within the community, career development of scientists and academic clinicians in aging and cancer research, and the development of pioneering collaborative research in the etiology, prevention, and management of cancer among those ages 65 and older. This will be accomplished via educational programs, career development strategies, and the support of innovative research via pilot projects designed to lead to inter-related and collaborative R01-funded research projects. Initial pilot projects will be in clinical areas of geriatrics and oncology, which is consistent with our current strength at the University of Colorado. These pilot projects are designed to not only lead to future R01 grants, but also to provide career development opportunities for outstanding new investigators at the University of Colorado who have cross-training and academic career interests overlapping the areas of geriatrics and oncology. We regard these developing investigators as the future leaders for the Colorado Program in Aging and Cancer. Future pilot projects will be targeted to build aging and cancer research into the already strong basic science research at the UCHSC. With leadership by Dr. Tim Byers and Dr. Robert Schwartz will focus the resources of the Center on Aging and the Colorado Comprehensive Cancer Center to develop a strong multi-disciplinary Program in Aging and Cancer which will be integrated into the University of Colorado Comprehensive Cancer Center CCSG at the time of its next competing renewal in 2006.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
5P20CA103680-03
Application #
6941290
Study Section
Special Emphasis Panel (ZCA1-GRB-H (O1))
Program Officer
Shafik, Hasnaa
Project Start
2003-09-29
Project End
2008-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
3
Fiscal Year
2005
Total Cost
$655,915
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Porter, C C; Baturin, D; Choudhary, R et al. (2011) Relative fitness of hematopoietic progenitors influences leukemia progression. Leukemia 25:891-5
Fini, Mehdi A; Monks, Jenifer; Farabaugh, Susan M et al. (2011) Contribution of xanthine oxidoreductase to mammary epithelial and breast cancer cell differentiation in part modulates inhibitor of differentiation-1. Mol Cancer Res 9:1242-54
Tyagi, Alpna; Gu, Mallikarjuna; Takahata, Takenori et al. (2011) Resveratrol selectively induces DNA Damage, independent of Smad4 expression, in its efficacy against human head and neck squamous cell carcinoma. Clin Cancer Res 17:5402-11
Kemmler, Charles B; Clambey, Eric T; Kedl, Ross M et al. (2011) Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses. J Immunol 187:4431-9
Lukin, Kara; Fields, Scott; Guerrettaz, Lisa et al. (2011) A dose-dependent role for EBF1 in repressing non-B-cell-specific genes. Eur J Immunol 41:1787-93
Patnaik, Jennifer L; Byers, Tim; DiGuiseppi, Carolyn et al. (2011) Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort study. Breast Cancer Res 13:R64
Patnaik, Jennifer L; Byers, Tim; Diguiseppi, Carolyn et al. (2011) The influence of comorbidities on overall survival among older women diagnosed with breast cancer. J Natl Cancer Inst 103:1101-11
Denberg, Thomas D; Kraus, Hanna; Soenksen, Alyssa et al. (2010) Rates of screening colonoscopy are not increased when women are offered a female endoscopist in a health promotion outreach program. Gastrointest Endosc 72:1014-9
Henry, Curtis J; Marusyk, Andriy; Zaberezhnyy, Vadym et al. (2010) Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proc Natl Acad Sci U S A 107:21713-8
Johnson, Thomas R; Koul, Sweaty; Kumar, Binod et al. (2010) Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: regulation of MMP 9 by PDEF. Mol Cancer 9:148

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