) The Seattle Cancer and Aging Program is a coordinated response between the Fred Hutchinson Cancer Research Center and the University of Washington Nathan Shock Center for aging research to explore the connection of cancer and aging. This proposal is a research planning and development grant application to support activities that will expand the capacity of our NCI-designated Cancer Center to engage in research that concentrates on aging- and age-related aspects of human cancer. Our goal is to support research and educational activities that will promote the establishment of a formal interdisciplinary aging/cancer research """"""""Program"""""""" as a component of our NCI-funded Cancer Center Support Grant (CCSG). To achieve this goal we plan to fund a series of pilot projects that will foster new collaborations, yield promising research results, catalyze new independent research grants, and lay the foundation for a continuing unified research effort in cancer and aging. The consortium of the Fred Hutchinson Cancer Research Center and the University of Washington has an usually strong and diverse faculty with aging and cancer interest who will be able to take advantage of this support. In our initial series of pilot projects we first concentrate on the thematic area of the Biology of Aging and Cancer; as demonstrated in the proposal, future proposed pilots involve all of the seven thematic areas of support. We believe we are in an unique position to forge an interactive, top-rate cancer and aging program. We are blessed with top-rate researchers, state-of-the-art resources, and rock-solid institutional commitment to make this a successful program. We fully expect that the activities outlined in this proposal will lead to important discovery and lay the foundation for significant scientific effort in the future.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
1P20CA103728-01
Application #
6698960
Study Section
Special Emphasis Panel (ZCA1-GRB-H (O1))
Program Officer
Bhorjee, Jaswant
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
2003-09-30
Budget End
2004-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$663,999
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Williams, Lindsey N; Herr, Alan J; Preston, Bradley D (2013) Emergence of DNA polymerase ? antimutators that escape error-induced extinction in yeast. Genetics 193:751-70
Lai, Lisa A; Risques, Rosa Ana; Bronner, Mary P et al. (2012) Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer. Cancer Lett 320:180-8
Kwan, Elizabeth X; Foss, Eric; Kruglyak, Leonid et al. (2011) Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS Genet 7:e1002250
Herr, Alan J; Williams, Lindsey N; Preston, Bradley D (2011) Antimutator variants of DNA polymerases. Crit Rev Biochem Mol Biol 46:548-70
Herr, Alan J; Ogawa, Masanori; Lawrence, Nicole A et al. (2011) Mutator suppression and escape from replication error-induced extinction in yeast. PLoS Genet 7:e1002282
Risques, Rosa Ana; Lai, Lisa A; Himmetoglu, Cigdem et al. (2011) Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. Cancer Res 71:1669-79
Bianchi-Frias, Daniella; Vakar-Lopez, Funda; Coleman, Ilsa M et al. (2010) The effects of aging on the molecular and cellular composition of the prostate microenvironment. PLoS One 5:
Preston, Bradley D; Albertson, Tina M; Herr, Alan J (2010) DNA replication fidelity and cancer. Semin Cancer Biol 20:281-93
Syrjala, Karen L; Stover, Allison C; Yi, Jean C et al. (2010) Measuring social activities and social function in long-term cancer survivors who received hematopoietic stem cell transplantation. Psychooncology 19:462-71
Syrjala, Karen L; Yi, Jean C; Artherholt, Samantha B et al. (2010) Measuring musculoskeletal symptoms in cancer survivors who receive hematopoietic cell transplantation. J Cancer Surviv 4:225-35

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