The link between chronic oral infections and general health has been recognized since the early 20th century. During the last 2 decades, retrospective epidemiological studies and prospective longitudinal, as well as intervention, studies have supported that these chronic oral infections with accompanying chronic inflammation associate with various systemic diseases and their sequelae. This continuation application for the Center for the Biologic Basis of Oral/System Diseases (CBBO/SD) addresses major initiatives of the National Institute of Dental and Craniofacial Research (NIDCR) regarding improving oral and general health ofthe U.S. population. The CBBO/SD is organized into 3 cInical projects: Project 1: Chronic Inflammation at the Oral and Cervico/Vaginal Mucosa;Project 2: Physiology of the Stress Response in Patients with Temporomandibular Disorders and Fibromyalgia;Project 3: Coordinated Oral-Intestinal Immune Response in Patients with Inflammatory Bowel Diseases;and 2 translational science projects: Project 4: Ontogeny of Innate Immune Responses at Mucosal Surfaces;and Project 5: Gene Therapy for Orofacial Pain. These projects enlist junior investigators from the Colleges of Dentistry, Nursing, and Medicine, as well as senior mentors/co-investigators from multiple colleges at UK. The thematic interface of the projects focuses on the contribution of chronic inflammation to oral and systemic diseases. They engage populations of expectant women, patients with chronic orofacial pain, and inflammatory bowel disease. These clinical projects interact with the translational projects at the level of a common understanding of innate immune responses and inflammation, and novel therapeutic intervention strategies forthe chronic orofacial pain. The CBBO/SD provides an infrastructure for development of the junior faculty by providing grants management support, educational opportunities, a biostatistics/bioinformatics core, and a clinical research center. The continuation of the CBBO/SD is supported by the success during the initial tenure of the center in transitioning junior investigators towards independent funding, coupled with substantial investment from the university and individual colleges.
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| Ebersole, Jeffrey L; Novak, Michael John; Orraca, Luis et al. (2018) Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. Immunology 154:452-464 |
| Gonzalez, O A; Kirakodu, S; Novak, M J et al. (2018) Comparative analysis of microbial sensing molecules in mucosal tissues with aging. Immunobiology 223:279-287 |
| Ebersole, J L; Dawson 3rd, D A; Emecen Huja, P et al. (2018) Age and Periodontal Health - Immunological View. Curr Oral Health Rep 5:229-241 |
| Ebersole, J L; Peyyala, R; Gonzalez, O A (2018) Biofilm Induced Profiles of Immune Response Gene Expression by Oral Epithelial Cells. Mol Oral Microbiol : |
| Ferrin, John; Kirakodu, Sreenatha; Jensen, David et al. (2018) Gene expression analysis of neuropeptides in oral mucosa during periodontal disease in non-human primates. J Periodontol 89:858-866 |
| Ebersole, Jeffrey L; Orraca, Luis; Kensler, Terry B et al. (2018) Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques. J Periodontal Res : |
| Ebersole, J L; Kirakodu, S; Novak, M J et al. (2018) Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease. Immunobiology : |
| Ebersole, Jeffrey L; Al-Sabbagh, Mohanad; Gonzalez, Octavio A et al. (2018) Ageing effects on humoral immune responses in chronic periodontitis. J Clin Periodontol 45:680-692 |
| Nagarajan, Radhakrishnan; Al-Sabbagh, Mohanad; Dawson 3rd, Dolph et al. (2017) Integrated biomarker profiling of smokers with periodontitis. J Clin Periodontol 44:238-246 |
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