The long-term goal of the Center of Biomedical Research Excellence (COBRE) is to develop a multidisciplinary translational research center focusing on discovering cartilage and joint health and disease mechanisms and developing repair strategy. During the Phase I of COBRE, great progress has been made in mentoring junior investigators into leaders of R01 grant funded research programs. The main objective of the Phase II COBRE is to sustain the success by recruiting more promising junior investigators into the COBRE research programs thereby further expanding and enhancing the base of skeletal research in Rhode Island Hospital and Brown University. The new research projects encompass clinical, biological, and engineering research fields. Project 1 analyzes how mechanical loading affects long bone growth during skeletal development. Project 2 examine how joint cartilage degenerates in adult joint diseases. Project 3 develops novel strategies of harvesting stem cells from fat tissues to repair bone. The investigators and mentors are selected from three departments in Rhode Island Hospital/The Alpert Medical School of Brown University (Orthopaedics, Medicine, and Molecular Pharmacology, Physiology, and Biotechnology). The junior investigators include a biologist, a bioengineer, and a clinician/scientist. The mentors also include biologists, engineers, and clinician/scientists. Eachmentor is a Principal Investigator of multiple federal grants including NIH R01. They will supervise junior investigator's research projects, serve as their role models, and mentor them to obtain federal research project grants. Our vision is, by sustaining and developing this research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers. This multidisciplinary approach is absolutely necessary to develop translational strategies for prevention and treatment of skeletal joint diseases.

Public Health Relevance

Cartilage and joint diseases, a research focus of our COBRE, are a leading cause of disability nationally, affecting an estimated 46.4 million U.S. citizens -more than one in every five adults aged 18 or older. The alarming figures of cartilage and joint diseases are compounded by the enormous costs we bear for arthritis treatment, its complications and the resulting disability. The prevalence of the join disease rates illustrates the significance for research, treatment, and prevention of these debilitating diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM104937-08
Application #
8725700
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Liu, Yanping
Project Start
2007-09-10
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Rhode Island Hospital
Department
Type
DUNS #
City
Providence
State
RI
Country
United States
Zip Code
02903
Janke, Abigail M; Seo, Da Hee; Rahmanian, Vahid et al. (2018) Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment. Biochemistry 57:2549-2563
Gil, Joseph A; Chambers, Alison; Shah, Kalpit N et al. (2018) A Biomechanical Evaluation of a 2-Suture Anchor Repair Technique for Thumb Metacarpophalangeal Joint Ulnar Collateral Ligament Injuries. Hand (N Y) 13:581-585
Pidgeon, Tyler S; Crisco, Joseph J; Waryasz, Gregory R et al. (2018) Ulnar Styloid Base Fractures Cause Distal Radioulnar Joint Instability in a Cadaveric Model. Hand (N Y) 13:65-73
Beveridge, Jillian E; Machan, Jason T; Walsh, Edward G et al. (2018) Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL. J Orthop Res 36:1701-1709
Wang, Shaowei; Wei, Xiaochun; Sun, Xiaojuan et al. (2018) A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system. Int J Nanomedicine 13:617-631
Zuo, Chunlin; Wang, Lijun; Kamalesh, Raghavendra M et al. (2018) SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity. Bone Res 6:12
Liu, Qihai; Wang, Jun; Chen, Yupeng et al. (2018) Suppressing mesenchymal stem cell hypertrophy and endochondral ossification in 3D cartilage regeneration with nanofibrous poly(l-lactic acid) scaffold and matrilin-3. Acta Biomater 76:29-38
Mansuripur, P Kaveh; Gil, Joseph A; Cassidy, Dale et al. (2018) Fixation Strength in Full and Limited Fixation of Osteoporotic Distal Radius Fractures. Hand (N Y) 13:461-465
Labriola, Nicholas R; Sadick, Jessica S; Morgan, Jeffrey R et al. (2018) Cell Mimicking Microparticles Influence the Organization, Growth, and Mechanophenotype of Stem Cell Spheroids. Ann Biomed Eng 46:1146-1159
Wang, Ailin; Conicella, Alexander E; Schmidt, Hermann Broder et al. (2018) A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J 37:

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