A.1. Overview. The prevalence of childhood and adolescent obesity is increasing at alarming rates. Theprevalence of overweight among adolescents aged 12 to 19 has tripled between 1980 and 2004 (Ogden et al.,2006). The obesity rates are highest among African American and Hispanic youth (National Center for Disease.Statistics, 2004). Co-morbid conditions are increasingly seen in obese youth, including insulin resistance, type2 diabetes, hypertension, obstructive sleep apnea, poor self-esteem, lower health-related quality of life (Rashid& Roberts, 2000; Rosenbloom, 2002; Sorof, Lai, Turner, Poffenbarger, & Portman, 2004; Wing et al., 2003).Moreover, these conditions tend to track into adulthood for 80% of obese youth (Whitaker, Wright, Pepe,Siedel, & Dietz, 1997). Given the rapidly growing prevalence of obesity in youths, developing evidence-basedweight loss treatments that not only achieve weight loss but facilitate sustainability of healthy weight areneeded, particularly for low income racially and ethnically diverse populations where the prevalence ofoverweight is highest. Novel approaches to promoting sustained healthy weight control through behavioralstrategies that lead to improvements in adequate physical activity participation in youths are a critical area ofresearch that has not been adequately tested through well-controlled trials. We will test the use of anintegrated in-person and Internet-based program that will target increased physical activity and decreasedsedentary behavior in overweight boys and girls from the Boston area. The program will utilize behavioralstrategies including self-monitoring, goal setting, social support, problem solving and others to promotesustained health behavior change in adolescents. Technology may be a particularly effective tool for deliveringsuch interventions because interactive technologies: 1) are routinely used throughout daily life by mostadolescents, for example, the 2004 Boston Youth Survey indicated that 76% of boys and 72% of girls from aethnically and racially diverse sample have access to the Internet at home (BYS, 2004), 2) have been shown inpreliminary studies to increase health behavior change in youth and adults (c.f.., Williamson et al., 2005), and3) can be delivered in a cost efficient way to large numbers of participants.Several reviews of the literature on technology-based intervention to address adolescent weight control haveidentified a number of limitations including 1) small sample sizes, 2) inadequate measures of bodycomposition, 3) inattention to the impact of physical development in the analyses, 4) failure to disaggregateresults for boys and girls separately , and 5) lack of follow-up (Atlantis, Barnes, Fiatarone, & Singh, 2006; Boon& Clydesdale, 2005; Snethen, Broome, & Cashin, 2006). Of the studies that specifically tested Internet-basedprograms, all but two studies were quasi-experimental in design, both had random assignment to groups.Moreover, the use of theory was limited in these studies, an important component. Finally, the outcomemeasures in previous studies were self-report and the sample sizes were typically small. Thus, whilepreliminary results are promising for the use of technology for physical activity and nutrition promotionprograms in youth, there is a critical need to rigorously test the efficacy of an Internet-based program to aid inthe adoption and maintenance of weight loss in a trial that is well-designed, with objective outcome measures,adequately powered, theoretically-based, and that has implications for weight loss on a larger-scale.We propose to design an innovative program for weight loss by targeting increased physical activity anddecreased sedentary time. Specifically, we intend to test a 3-month supervised exercise program that alsoincludes comprehensive, theoretically-based, in-person and Internet behavioral coaching to promote physicalactivity for weight loss (Exercise + Internet Coaching) versus a 3-month standard supervised exercise program(Exercise). In this way, we will be able to test whether or not the addition of the in-person and Internetbehavioral coaching assists in the achievement and maintenance of a reduction in body fat via promotion ofphysical activity and a reduction in sedentary time.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
1P20MD002290-01
Application #
7305393
Study Section
Special Emphasis Panel (ZRG1-DIG-C (52))
Project Start
2007-01-01
Project End
2012-05-30
Budget Start
2007-01-01
Budget End
2008-05-31
Support Year
1
Fiscal Year
2007
Total Cost
$403,506
Indirect Cost
Name
University of Massachusetts Boston
Department
Type
DUNS #
808008122
City
Boston
State
MA
Country
United States
Zip Code
02125
Ravenelle, Rebecca; Berman, Ariel K; La, Jeffrey et al. (2018) Sex matters: females in proestrus show greater diazepam anxiolysis and brain-derived neurotrophin factor- and parvalbumin-positive neurons than males. Eur J Neurosci 47:994-1002
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Mian, Nicholas D; Eisenhower, Abbey S; Carter, Alice S (2015) Targeted prevention of childhood anxiety: engaging parents in an underserved community. Am J Community Psychol 55:58-69
Cholanian, Marina; Lobzova, Anna; Das, Bhargab et al. (2014) Digital holographic microscopy discriminates sex differences in medial prefrontal cortex GABA neurons following amphetamine sensitization. Pharmacol Biochem Behav 124:326-32
Ravenelle, Rebecca; Neugebauer, Nichole M; Niedzielak, Timothy et al. (2014) Sex differences in diazepam effects and parvalbumin-positive GABA neurons in trait anxiety Long Evans rats. Behav Brain Res 270:68-74
Ravenelle, R; Santolucito, H B; Byrnes, E M et al. (2014) Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats. Neuroscience 270:76-87
Berman, Ariel Kupfer; Lott, Rhonda B; Donaldson, S Tiffany (2014) Periodic maternal deprivation may modulate offspring anxiety-like behavior through mechanisms involving neuroplasticity in the amygdala. Brain Res Bull 101:7-11
Godoy, Leandra; Mian, Nicholas D; Eisenhower, Abbey S et al. (2014) Pathways to service receipt: modeling parent help-seeking for childhood mental health problems. Adm Policy Ment Health 41:469-79
Eisenhower, Abbey; Suyemoto, Karen; Lucchese, Fernanda et al. (2014) ""Which box should I check?"": examining standard check box approaches to measuring race and ethnicity. Health Serv Res 49:1034-55

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