This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Core Facility for Imaging provides sophisticated digital imaging capabilities from macroscopic to electron microscopic levels of resolution and assists researchers with imaging needs ranging from basic histology, immunofluorescence and electron microscopy to digital image processing and analysis. Specific goals of the Facility are to develop and to disseminate a core of expertise in experimental design and image acquisition, to maintain and provide access to instruments and analytical tools that individual laboratory budgets generally are incapable of sustaining, and to provide imaging-related services particularly for short-term, or during the preliminary or early phases of, research projects. Throughout, the emphasis of the Facility is to acquire, process, analyze and produce state-of-the-art digital images. Over the past year, in each month, more than 150 investigators, technicians and students representing 29 laboratories from across Oklahoma have used the Facility, and Imaging Facility efforts have been included in approximately 1 new publication per week on average. This work derives from an estimated stable user base of 69 Principal Investigators overall. Use by COBRE-funded investigators accounts for about 1/2 of the total useage of the Facility, based on the numbers of projects. For example, during fiscal year 2003, work performed in or by the Imaging Facility appeared in 21 posters, 11 grants (applied for) and 19 papers from COBRE-funded investigators alone. If anything, its use has increased by 25 percent each year since. The Core Facility for Imaging contributes substantially to the research capabilities of investigators included in this COBRE proposal as well as to investigators at OMRF, OUHSC, and throughout the state of Oklahoma.
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