The loss of cognitive function with normal aging is well known and while clearly different from the catastrophic loss of memory seen in Alzheimer's disease and the other age-related dementias, is of concern to an increasing number of Americans. This application seeks support to recruit an outstanding junior faculty member to the Taub Institute at Columbia University to study the normal aging process in either the animal or the human brain.
An understanding of the mechanisms of normal aging in the brain is critical if we are to slow cognitive decline in our aging population. It will enable us to understand the factors that lead to accelerated cognitive decline and dementia.
Aubry, Soline; Shin, William; Crary, John F et al. (2015) Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression. PLoS One 10:e0120352 |
Santa-Maria, Ismael; Alaniz, Maria E; Renwick, Neil et al. (2015) Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau. J Clin Invest 125:681-6 |
Crary, John F; Trojanowski, John Q; Schneider, Julie A et al. (2014) Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol 128:755-66 |
Santa-Maria, Ismael; Haggiagi, Aya; Liu, Xinmin et al. (2012) The MAPT H1 haplotype is associated with tangle-predominant dementia. Acta Neuropathol 124:693-704 |