The Biostatistics and Data Management Core (BDMC) is being established to provide centralized access for CFAR investigators to services that are critical to the success for HIV/AIDS-related research. The goals of the BDMC are to provide 1) biostatistics/clinical epidemiology study design and analysis support, 2) data management consultation and services, and 3) database development consultation and services, to enhance the quality of the work performed by CFAR investigators.
The aims of the BDMC are to i) advise investigators on study design issues, ii) (re)define and/or refine study hypotheses; iii) conduct sample size/power analyses for basic science/laboratory studies and clinical protocols; iv) provide scientific input into the design and testing of data collection instruments; v) coordinate data management and database development activities; vi) assist with preparation for and writing of final reports, abstracts, manuscripts, and future research proposals; viii) conduct exploratory analyses that may lead to generation of new hypothesis. Core members will facilitate scientific collaboration and translational HIV/AIDS-related research by consulting on study design and analysis; eventually bringing positive basic science results to the attention of clinical researchers. The Core will contribute to the quality of clinical research by consulting with clinical researchers on the development of standardized methodologies for the collection and management of data. The Core will emphasize the necessity for data management methodologies that are compliant with applicable FDA and ICH (International Conference for Harmonization) guidelines. Industry collaboration and funding will be encouraged through assurances that research is conducted in a manner consistent with regulatory requirements. The Core will provide leadership for the database and date warehouse development activities, coordinating the integration of separate, remotely located clinical databases into a centrally located data warehouse. These activities include 1) identification of remotely, individually managed data sources; 2) development of a clinical care cohort intake and update Data Management System (DMS); 3) development of a CFAR data warehouse, a distinct centralized data repository that contains extracts of vital scientific data from all individual sources. This data warehouse will function as a subject registry and a repository that contains extracts of vital scientific data from all individual data sources. This data warehouse will function as a subject registry and a repository of clinical data, supporting project-specific and institution-wide HIV/AIDS-related research. Additionally, the data warehouse will function as a catalog of biological specimens. This centralized catalog facility will communicate to investigators the availability of specimens and will allow more efficient access to specimens; thereby facilitating usage of these valuable specimens.
| Crits-Christoph, Paul; Gallop, Robert; Noll, Elizabeth et al. (2018) Impact of a medical home model on costs and utilization among comorbid HIV-positive Medicaid patients. Am J Manag Care 24:368-375 |
| Sherrill-Mix, Scott; McCormick, Kevin; Lauder, Abigail et al. (2018) Allometry and Ecology of the Bilaterian Gut Microbiome. MBio 9: |
| Kadimisetty, Karteek; Song, Jinzhao; Doto, Aoife M et al. (2018) Fully 3D printed integrated reactor array for point-of-care molecular diagnostics. Biosens Bioelectron 109:156-163 |
| Li, Binglan; Verma, Shefali S; Veturi, Yogasudha C et al. (2018) Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. Pac Symp Biocomput 23:448-459 |
| Fraietta, Joseph A; Nobles, Christopher L; Sammons, Morgan A et al. (2018) Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells. Nature 558:307-312 |
| Kelly, Matthew S; Surette, Michael G; Smieja, Marek et al. (2018) Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana. Pediatr Infect Dis J 37:1176-1183 |
| Chitre, Avantika S; Kattah, Michael G; Rosli, Yenny Y et al. (2018) A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog 14:e1006806 |
| Milligan, Michael G; Bigger, Elizabeth; Abramson, Jeremy S et al. (2018) Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana. J Glob Oncol :1-11 |
| Medvec, Andrew R; Ecker, Christopher; Kong, Hong et al. (2018) Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium. Mol Ther Methods Clin Dev 8:65-74 |
| Washio, Yukiko; Novack Wright, Elizabeth; Davis-Vogel, Annet et al. (2018) Prior Exposure to Intimate Partner Violence Associated With Less HIV Testing Among Young Women. J Interpers Violence :886260518768564 |
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