The Biology of Colon Cancer is program remains focused on fundamental cellular and molecularmechanisms of intestinal cell maturation and lineage specific differentiation, and how this establishes andmaintains homeostasis of the intestinal mucosa; genetic and environmental factors, and their interactions,that perturb these processes and alter probability of tumor formation and progression; and approaches toprevent tumorigenesis and treat intestinal cancer. Members utilize novel cell systems in culture, mousegenetic models, and human tissues and subjects in their investigations. All of the members areindependently funded by grants that are highly cancer focused, and most participate in large multidisciplinaryprograms that are jointly funded. During the last funding period, this included an NCI U01 Director'sChallenge grant on molecular markers of relative drug sensitivity in colon cancer, and subsequently an NCIU54 Center grant on nutritional-genetic interactions in intestinal cancer. This joint funding, and a largenumber of joint publications, reflects the extensive interactions and collaborations among members of theProgram. Moreover, members of the Program collaborate widely across the AECC and have made uniqueresources available to other Center members. The Program has continued to grow during the last 5 years,both by promotion from within and recruitment, made possible by support from the AECC and a pilot projectprogram funded by the U54 Center grant. Leonard Augenlicht remains the Leader of this Program.There are currently 12 program members from 8 departments, of whom 11 are primary members, supportedby 15 NCI ($3.7M Direct) and 2 other NIH grants. Five members are new to the program. Since the lastCCSG review there have been 105 cancer-relevant research papers by members of this program of which34% represent intraprogrammatic, and 33% represent interprogrammatic publications.
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