Abstract

The research of the MIT Center for Cancer Research (CCR) faculty is focused on elucidating the basic mechanisms of cancer development. It is organized into three distinct programs organized around shared common interests and overlapping long-term goals. These are Program 1: Molecular Genetics and Immunology; Program 2: Genetics and Model Systems; Program 3: Cell Biology. As an NCI-designated basic research center, the CCR is both a physical entity and an organizing body for MIT's cancer research community at large. Of the thirty member laboratories, eleven are located in the Center's home building (E 17/18), the others are located in the Koch Biology Building (4), the Broad Institute (2), Whitehead Institute (7), the Division of Biological Engineering (4), and the Department of Chemistry (1) and the Department of Chemical Engineering (1). The Center functions to facilitate interactions among the member laboratories, foster research collaborations, provide integral core facilities as well as seed funding for cancer research. The Center operates or shares in support of eleven core facilities that provide access for member laboratories to critical research technologies, materials, infrastructure and trained personnel. It also trains a large number of graduate students, postdoctoral fellows, clinical fellows and undergraduate students in basic cancer research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-35
Application #
7117033
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
1997-06-17
Project End
2010-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
35
Fiscal Year
2006
Total Cost
$2,899,999
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Internal Medicine/Medicine
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Guen, Vincent J; Edvardson, Simon; Fraenkel, Nitay D et al. (2018) A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness. Am J Med Genet A 176:92-98
Murphy, Patrick A; Butty, Vincent L; Boutz, Paul L et al. (2018) Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Elife 7:
Khan, Omar F; Kowalski, Piotr S; Doloff, Joshua C et al. (2018) Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles. Sci Adv 4:eaar8409
Woolston, Benjamin M; Roth, Timothy; Kohale, Ishwar et al. (2018) Development of a formaldehyde biosensor with application to synthetic methylotrophy. Biotechnol Bioeng 115:206-215
Huang, Hsin-Ho; Qian, Yili; Del Vecchio, Domitilla (2018) A quasi-integral controller for adaptation of genetic modules to variable ribosome demand. Nat Commun 9:5415
Guimarães, Pedro P G; Gaglione, Stephanie; Sewastianik, Tomasz et al. (2018) Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano 12:912-931
Moynihan, Kelly D; Holden, Rebecca L; Mehta, Naveen K et al. (2018) Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability. Cancer Immunol Res 6:1025-1038
Nath, Samir R; Yu, Zhigang; Gipson, Theresa A et al. (2018) Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. J Clin Invest 128:3630-3641
Kimmerling, Robert J; Prakadan, Sanjay M; Gupta, Alejandro J et al. (2018) Linking single-cell measurements of mass, growth rate, and gene expression. Genome Biol 19:207
Rothenberg, Daniel A; Taliaferro, J Matthew; Huber, Sabrina M et al. (2018) A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9:367-381

Showing the most recent 10 out of 904 publications