? RECRUITMENT, INTERVENTION AND SURVEY SHARED RESOURCE (RISSR) The RISSR was established in 2003, as the Behavioral Measurement Shared Resource (BMSR), to provide a mechanism for supporting behavioral, epidemiological and clinical research within the broader research goals of the OSUCCC. Renamed in 2019, the RISSR provides essential services to support non-interventional studies (observational, epidemiologic) as well as non-therapeutic intervention studies. Thus, the RISSR is a niche service for population scientists in CC and MCC providing efficient and high quality services for investigators to conduct population science research. RISSR also works with the BSSR to support the Total Cancer Care (TCC) project accruals, and translational research involving human data collection and interventions for all 5 research programs. For the next funding period, the RISSR specific aims are to: 1) provide expertise in research design, the selection and/or development of surveys and study measures, including patient-reported outcomes; 2) assist investigators with participant recruitment, accrual goals, and retention to ensure the inclusion of research participants that are representative of the target population(s); and 3) provide investigators with expertise and services in the collection and management of quantitative and qualitative research data, and population-based data retrieval for grant applications and registry studies. Collected data are managed for seamless transfer to the BSR for data analysis. Over the current funding cycle, the major changes to the RISSR were greater adoption of electronic data collection for the majority of OSUCCC studies, using text messaging with participants for more flexible communication, data collection and study conduct; increased use of mobile health interventions; and providing support for more program projects and large multi-heath center/ multi-state research projects. During the current funding cycle, RISSR has supported 35 principal investigators (54% OSUCCC members) and contributed to 71 publications (1 >10 impact factor) and 9 NCI grants including 1 K01, 1 K07, 1 K12, 1 P01, 2 P50s, 2 R01s, and 1 R37. The RISSR will directly support the OSUCCC priority for immune-oncology and cancer prevention and control. The RISSR will expand its staff, instrumentation and services before capacity is reached. In the next funding cycle, the RISSR will: 1) further develop and customize survey and data collection methods; 2) expand and support participant recruitment registries for rapid accrual for interventional and epidemiological studies; 3) expand the provision of smart phones to study participants to reduce disparities in participant recruitment and participation; and 4) develop greater linkages with the BISR to share computer platforms and expertise related to clinical informatics, eHealth interventions using the electronic health record, and health services research. The RISSR will also work with the BSR and BISR as part of the Biomedical Informatics Coordinating Center (BMICC) Working Group to establish national data coordinating centers at the OSUCCC on cancer-related topics. The annual budget of the RISSR is $1,631,722, yet the CCSG request is $92,102 (5.6%) reflecting strong institutional support and a robust chargeback system.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016058-45
Application #
10090018
Study Section
Subcommittee H - Clinical Groups (NCI)
Project Start
1997-09-12
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Talbert, Erin E; Lewis, Heather L; Farren, Matthew R et al. (2018) Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients. J Cachexia Sarcopenia Muscle 9:358-368
Wang, Jin-Ting; Xie, Wen-Quan; Liu, Fa-Quan et al. (2018) NADH protect against radiation enteritis by enhancing autophagy and inhibiting inflammation through PI3K/AKT pathway. Am J Transl Res 10:1713-1721
Karpurapu, Manjula; Lee, Yong Gyu; Qian, Ziqing et al. (2018) Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis. Oncotarget 9:10606-10620
Norquist, Barbara M; Brady, Mark F; Harrell, Maria I et al. (2018) Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study. Clin Cancer Res 24:777-783
Zhang, Bin; Nguyen, Le Xuan Truong; Li, Ling et al. (2018) Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nat Med 24:450-462
Tasselli, Giorgia; Filippucci, Sara; Borsella, Elisabetta et al. (2018) Yeast lipids from cardoon stalks, stranded driftwood and olive tree pruning residues as possible extra sources of oils for producing biofuels and biochemicals. Biotechnol Biofuels 11:147
Moliva, J I; Hossfeld, A P; Canan, C H et al. (2018) Exposure to human alveolar lining fluid enhances Mycobacterium bovis BCG vaccine efficacy against Mycobacterium tuberculosis infection in a CD8+ T-cell-dependent manner. Mucosal Immunol 11:968-978
Suarez-Kelly, Lorena P; Akagi, Keiko; Reeser, Julie W et al. (2018) Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity. Cold Spring Harb Mol Case Stud 4:
Malpeli, Giorgio; Barbi, Stefano; Greco, Corinna et al. (2018) MicroRNA signatures and Foxp3+ cell count correlate with relapse occurrence in follicular lymphoma. Oncotarget 9:19961-19979
McRee, Annie-Laurie; Shoben, Abigail; Bauermeister, Jose A et al. (2018) Outsmart HPV: Acceptability and short-term effects of a web-based HPV vaccination intervention for young adult gay and bisexual men. Vaccine 36:8158-8164

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