Community Outreach and Engagement ABSTRACT The City of Hope Comprehensive Cancer Center (COHCCC) is a freestanding cancer center whose main campus is located in Duarte, California. The COHCCC Catchment Area includes the entirety of Los Angeles and Orange Counties and portions of Ventura, Riverside, and San Bernardino Counties. The Catchment Area is bounded by the Pacific Ocean to the south and west; Antelope Valley to the north; Santa Clarita and Simi Valley to the west; the metropolitan areas of Riverside and San Bernardino to the east; and the communities of Palm Desert, Murrieta, and San Clemente to the south. The COHCCC Catchment Area covers 9,365 square miles and includes the heart of the greater Los Angeles metropolitan area and more inland communities. We serve a multi-racial, multi-ethnic community of over 17.1 million individuals, which represents approximately 40 percent of all Californians. Remarkably, the population of our Catchment Area is greater than the individual populations of 46 states and greater than the populations of 14 states combined. The COHCCC seeks to use its research and resources to improve the lives of the men, women, and children who live in our Catchment Area, particularly in the more inland regions. The residents we serve face challenges that impact cancer survival, including poverty, obesity, and lack of access. These challenges are uniformly faced whether an individual comes from urban or more rural environments. To achieve this goal, COHCCC has three themes: 1. Identify and pursue challenging questions in cancer research relevant to the people of our Catchment Area. 2. Develop and implement strategies for including underserved populations in our programmatic research. 3. Take advantage of research discoveries, collaborations, networks, and affiliates to extend our reach and to implement creative interventions to increase access and health equity within our Catchment Area, as well as nationally and internationally. To reduce the incidence of cancer in the unique populations we serve within our Catchment Area, we identified the following priorities: ? Biologically aggressive cancers that impact diverse populations in our COHCCC Catchment Area ? Viral-related cancers, including hepatocellular carcinoma and HIV-related malignancies ? Impact of pollution on cancer incidence, with a focus on breast and lung cancer ? Cancers of aging in Asian- and Latino-Americans

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA033572-38
Application #
10059212
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
1997-08-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
38
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Gong, Jun; Salgia, Ravi (2018) Managing Patients With Relapsed Small-Cell Lung Cancer. J Oncol Pract 14:359-366
Chen, Robert W; Palmer, Joycelynne M; Tomassetti, Sarah et al. (2018) Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation. J Hematol Oncol 11:87
Romsdahl, Jillian; Blachowicz, Adriana; Chiang, Abby J et al. (2018) Characterization of Aspergillus niger Isolated from the International Space Station. mSystems 3:
Sen, Subha; He, Zhiheng; Ghosh, Shubhamoy et al. (2018) PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5. J Immunol 201:440-450
Lueschow, Shiloh R; Stumphy, Jessica; Gong, Huiyu et al. (2018) Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis. PLoS One 13:e0204967
Gu, Long; Lingeman, Robert; Yakushijin, Fumiko et al. (2018) The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res 24:6053-6065
Zhao, Xingli; Zhang, Zhuoran; Moreira, Dayson et al. (2018) B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors. Mol Ther 26:695-707
Weitzel, Jeffrey N; Chao, Elizabeth C; Nehoray, Bita et al. (2018) Somatic TP53 variants frequently confound germ-line testing results. Genet Med 20:809-816
Ghose, Jayeeta; Viola, Domenico; Terrazas, Cesar et al. (2018) Daratumumab induces CD38 internalization and impairs myeloma cell adhesion. Oncoimmunology 7:e1486948
Aslamy, Arianne; Oh, Eunjin; Olson, Erika M et al. (2018) Doc2b Protects ?-Cells Against Inflammatory Damage and Enhances Function. Diabetes 67:1332-1344

Showing the most recent 10 out of 1396 publications