Abstract

The Genotyping Shared Resource (GSR) was established in 1999 with the mission to provide genotyping and nucleic acid extraction services in support of the peer-reviewed and IRB-approved research conducted by CRCH members. The goal is to take advantage of the genetic heterogeneity of Hawaii multiethnic population and translate information available on the human genome into new knowledge about cancer etiology, prevention and treatment. The tests performed by the GSR laboratory have included a large number of polymorphism detection assays for genes involved in DNA synthesis or repair, cell proliferation, or metabolism of xenobiotics, nutrients, or endogenous hormones. All users are CRCH members with nationally peer-reviewed, cancer-related grants. During the current grant cycle, the GSR has experienced an exceptional growth, both in terms of the amount of use (43-fold increase) and the number of grants supported (+140%), and has already led to a large number of peer-reviewed publications (n=31). By providing key equipment and core personnel, the P30 grant has played a critical role in this success. Continued support is requested from the CCSG for core operational activities. The remaining costs will continue to be covered from grants through a charge-back mechanism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA071789-12
Application #
7680242
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
12
Fiscal Year
2008
Total Cost
$85,474
Indirect Cost

  Institution

Name
University of Hawaii
Department
Type
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822

  Publications

Marciel, Michael P; Khadka, Vedbar S; Deng, Youpeng et al. (2018) Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget 9:13407-13422
Park, S-Y; Wilkens, L R; Maskarinec, G et al. (2018) Weight change in older adults and mortality: the Multiethnic Cohort Study. Int J Obes (Lond) 42:205-212
Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390
Pokhrel, Pallav; Herzog, Thaddeus A; Fagan, Pebbles et al. (2018) E-cigarette Advertising Exposure, Explicit and Implicit Harm Perceptions, and E-Cigarette use Susceptibility Among Non-Smoking Young Adults. Nicotine Tob Res :
Wu, Eric M; Hernandez, Brenda Y; Wong, Linda L (2018) Hepatocellular carcinoma in Micronesians, a growing Pacific Islander population in the U.S. Open J Gastroenterol 8:
Murphy, Sharon E; von Weymarn, Linda B; Parenteau, Marc et al. (2018) Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. Chem Res Toxicol 31:168-175
Loo, Lenora W M; Williams, Makana; Hernandez, Brenda Y (2018) The high and heterogeneous burden of breast cancer in Hawaii: A unique multiethnic U.S. Population. Cancer Epidemiol 58:71-76
Hernandez, Brenda Y; Tareg, Aileen C; Reichhardt, Martina et al. (2018) Randomized controlled trial evaluating the utility of urine HPV DNA for cervical cancer screening in a Pacific Island population. J Glob Health Rep 2:
Gu, Yuanzhuo; Wei, Xiyang; Sun, Yulin et al. (2018) miR-192-5p silencing by genetic aberrations is a key event in hepatocellular carcinomas with cancer stem cell features. Cancer Res :
Lim, Unhee; Monroe, Kristine R; Buchthal, Steve et al. (2018) Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups. Gastroenterology :

Showing the most recent 10 out of 562 publications