Otitis media is among the most common childhood diseases, and otitis media sequelae are frequent in adults. A multidisciplinary team of basic and clinical scientists has led otitis media research at the University of Minnesota since 1978, when the University's Otitis Media Research Center (OMRC) was formed. The OMRC mission is to create a collaborative environment for interdisciplinary research that stimulates advancement in understanding otitis media pathogenesis, to inspire new developments in diagnostic technology, treatment and prevention modalities, and to generate and disseminate fundamental and clinical knowledge, thereby, enhancing patient care. The Otitis Media Core Center will support 16 currently NIH-funded base research projects (12 NIDCD-funded) and an additional two recently submitted projects. OMRC research is focused in basic molecular, cellular, microbial, immunological, animal modeling, population science, and clinical studies. Research productivity is demonstrated in the more than 400 peer-reviewed publications from OMRC faculty. Most of the proposed Core Laboratories were developed under NIDCD P01 support from 1978 to 1996. The Analytical Pathobiology Core will continue to provide expertise and techniques in microbiology, immunology, biochemistry, molecular biology, and histopathology. It will also provide antibodies, probes, archival samples, bacteria or bacterial components, and a complete range of histological and molecular biological services on human and animal temporal bones. Services include light and electron microscopy, histochemistry, immunohistochemistry, immunogold, quantitative image analysis, Northern blot, RNA protection assay, Western blot, in situ hybridization, competitive RT-PCR, representative differential display, and molecular expression and cloning. Immunological expertise includes immunoassay development, immunological reagent production, molecular characterization of a pneumococcal library used in otitis media animal modeling, and refinement of animal modeling surgical techniques. The Human Subjects & Biostatistics Core will continue to be responsible for assisting base project PIs in study design, data collection and processing, quality control, data storage and retrieval, and data analysis of all studies to provide all investigators with a high level and broad range of expertise in data management and analysis. A unique feature of the Core will be the provision of pilot data for new projects drawing from databases and participants from previous OM studies. The key areas are quality control and standardization of data analyses. The key areas are in both Cores are quality assurance, assay standardization, and utilization of the most sensitive methodologies available. Together, the Cores will greatly enhance the OMRC infrastructure, allowing highly productive basic and clinical scientists to conduct research on a broad range of middle and inner ear disorders.
| Schachern, Patricia; Tsuprun, Vladimir; Cureoglu, Sebahattin et al. (2008) The round window membrane in otitis media: effect of pneumococcal proteins. Arch Otolaryngol Head Neck Surg 134:658-62 |
| Zhang, Quan-An; Hamajima, Yuki; Zhang, Qing et al. (2008) Identification of Id1 in acquired middle ear cholesteatoma. Arch Otolaryngol Head Neck Surg 134:306-10 |
| Fukushima, Hisaki; Harada, Tamotsu; Morita, Norimasa et al. (2008) Trisomy 13 syndrome. Otol Neurotol 29:1209-10 |
| Kariya, Shin; Schachern, Patricia A; Cureoglu, Sebahattin et al. (2008) Up-regulation of macrophage migration inhibitory factor induced by endotoxin in experimental otitis media with effusion in mice. Acta Otolaryngol 128:750-5 |
| Tsuchiya, Katsuyuki; Komori, Masahiro; Zheng, Qing Yin et al. (2008) Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse otitis media model. Ann Otol Rhinol Laryngol 117:630-6 |
| Fukushima, Hisaki; Schachern, Patricia A; Cureoglu, Sebahattin et al. (2008) Temporal bone study of trisomy 13 syndrome. Laryngoscope 118:506-7 |
| Tsuchiya, Katsuyuki; Toyama, Katsuhiro; Tsuprun, Vladimir et al. (2007) Pneumococcal peptidoglycan-polysaccharides induce the expression of interleukin-8 in airway epithelial cells by way of nuclear factor-kappaB, nuclear factor interleukin-6, or activation protein-1 dependent mechanisms. Laryngoscope 117:86-91 |
| Schachern, Patricia A; Cureoglu, Sebahattin; Tsuprun, Vladimir et al. (2007) Age-related functional and histopathological changes of the ear in the MPS I mouse. Int J Pediatr Otorhinolaryngol 71:197-203 |
| Kariya, Shin; Cureoglu, Sebahattin; Fukushima, Hisaki et al. (2007) Histopathologic changes of contralateral human temporal bone in unilateral Meniere's disease. Otol Neurotol 28:1063-8 |
| Segade, Fernando; Daly, Kathleen A; Allred, Dax et al. (2006) Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study. Arch Otolaryngol Head Neck Surg 132:729-33 |
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