The Immunology Core will be co-directed by Andrew Luster and Shiv Pillai. A variety of services will be provided by the Core. These include a number of novel and powerful approaches that can be applied to human immunology, for which the Core offers protocols, education, and bioinformatics analysis. In addition to these more innovative approaches, the Core also continues to provide access to established technologies such as high-speed cell sorting and cytokine assays. The services are organized into three major categories: (1) education and training, (2) routine immunology tools, and (3) specialized immunology services. By assisting investigators in developing assays and offering access to both standard techniques and a number of newly developing, powerful immunologic techniques, this core is fundamentally necessary for a number of studies pursued by CSIBD investigators and advanced trainees ready to emerge as independent investigators.
The specific aims of Immunology Core are to (1) provide CSIBD members with access to immunological resources that would otherwise be cost-prohibitive to individual researchers; (2) offer CSIBD investigators access to cutting-edge immunological techniques that are at the forefront of immunology research; and (3) promote the development of junior investigators and foster collaborations by providing a connection point between investigators of varying research approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK043351-30
Application #
9848614
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
30
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Hui, Ken Y; Fernandez-Hernandez, Heriberto; Hu, Jianzhong et al. (2018) Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med 10:
Zhang, Sidi; Samocha, Kaitlin E; Rivas, Manuel A et al. (2018) Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides. Genome Res 28:968-974
Beaulieu, Dawn B; Ananthakrishnan, Ashwin N; Martin, Christopher et al. (2018) Use of Biologic Therapy by Pregnant Women With Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines. Clin Gastroenterol Hepatol 16:99-105
Garber, John J; Mallick, Emily M; Scanlon, Karen M et al. (2018) Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. Cell Mol Gastroenterol Hepatol 5:273-288
Chong, Dawn Q; Banbury, Barbara L; Phipps, Amanda I et al. (2018) Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies. Cancer Med 7:2192-2199
Johns, Nathan I; Gomes, Antonio L C; Yim, Sung Sun et al. (2018) Metagenomic mining of regulatory elements enables programmable species-selective gene expression. Nat Methods 15:323-329
Cox, Kimberly H; Oliveira, Luciana M B; Plummer, Lacey et al. (2018) Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet 27:338-350
Yu, Sheng; Ma, Yumeng; Gronsbell, Jessica et al. (2018) Enabling phenotypic big data with PheNorm. J Am Med Inform Assoc 25:54-60
Bakker, Olivier B; Aguirre-Gamboa, Raul; Sanna, Serena et al. (2018) Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. Nat Immunol 19:776-786
Chhatwal, Jagpreet; Samur, Sumeyye; Bethea, Emily D et al. (2018) Transplanting hepatitis C virus-positive livers into hepatitis C virus-negative patients with preemptive antiviral treatment: A modeling study. Hepatology 67:2085-2095

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