The Center grant provides resources to support six program areas: 1) Human Exposure and Health Effects; 2) Epidemiology; 3) Environmental and Occupational Medicine; 4) Systemic Toxicology; 5) Environmental Carcinogenesis; and 6) Molecular and Genetic Toxicology. A major emphasis of the Center continues to be the study of environmental factors that affect human disease and disease exacerbations, as well as the development of methods for detection, prevention and control of environmentally related diseases. To tackle this vast array of problems, the Center has brought together and integrated the efforts of a multidisciplinary group of established scientists who are building on the resources of New York University Medical Center and the University community at large. In particular, research strengths at the institute include: l) DNA adducts, chemistry, mutagenesis; 2) metal toxicology and carcinogenesis; 3) oncogenes and tumor suppressor genes; 4) oxidative damage and chemoprevention; 5) radiation bioeffects; 6) biomarkers of exposure, response and susceptibility; 7) effects of ambient air pollutant exposures on lung structure function and disease progression; and 8) particle deposition and clearance from the lungs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES000260-33
Application #
2152955
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1975-01-01
Project End
2000-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
33
Fiscal Year
1995
Total Cost
Indirect Cost
Name
New York University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
Guo, Xirui; Huang, Haishan; Jin, Honglei et al. (2018) ISO, via Upregulating MiR-137 Transcription, Inhibits GSK3?-HSP70-MMP-2 Axis, Resulting in Attenuating Urothelial Cancer Invasion. Mol Ther Nucleic Acids 12:337-349
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Chen, Qiao Yi; Costa, Max (2018) PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis. Mol Pharmacol 94:784-792
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Lee, Hyun-Wook; Park, Sung-Hyun; Weng, Mao-Wen et al. (2018) E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A 115:E1560-E1569
Muñoz, Alexandra; Eldridge, Will J; Jakobsen, Nina Munkholt et al. (2018) Cellular shear stiffness reflects progression of arsenic-induced transformation during G1. Carcinogenesis 39:109-117
Harley, Naomi H (2018) Effect of Residential Radon Decay Product Dose Factor Variability on Reporting of Dose. Health Phys 114:398-407

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