Abstract

This application represents a competing renewal for a Vision Research Core Center Grant, now in it's tenth year, which funds support facilities and services for 25 researchers that comprise the Core faculty in the Cullen Eye Institute, Baylor College of Medicine. Major program areas include diseases of the retina and choroid: the cornea; and the sensory- motor visual system. Research activities include investigation of the anatomy, biochemistry, cell biology, physiology, molecular biology, immunology and pathology of the neural retina, retinal pigment epithelium, choroid, retinal organization and information processing, lens and cataractogenesis, the role of herpes viruses and corneal disease, endogenous fungal endophthalmitis, glaucoma and visual dysfunction in stabismus and amblyopia. Eight basic research support modules are proposed and are listed below in order of our prioritized needs. -Administration-Research Photography-Image Analysis-Electron Microscopy- Equipment-Research Workshop-Molecular Biology-Animal Facilities In addition, a clinical research support module is also proposed which will bring clinical researchers into our Core who have not previously been supported through this mechanism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY002520-13
Application #
3102528
Study Section
Vision Research and Training Committee (VSN)
Project Start
1979-07-01
Project End
1994-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
13
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Denfield, George H; Ecker, Alexander S; Shinn, Tori J et al. (2018) Attentional fluctuations induce shared variability in macaque primary visual cortex. Nat Commun 9:2654
Wang, Changjun; Zaheer, Mahira; Bian, Fang et al. (2018) Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci 19:
Kumar, Sandeep; Lambert, Alyssia; Rainier, Jon et al. (2018) Disruption of Rhodopsin Dimerization in Mouse Rod Photoreceptors by Synthetic Peptides Targeting Dimer Interface. Methods Mol Biol 1753:115-128
Zaneveld, Smriti Agrawal; Eblimit, Aiden; Liang, Qingnan et al. (2018) Gene Therapy Rescues Retinal Degeneration in Receptor Expression-Enhancing Protein 6 Mutant Mice. Hum Gene Ther :
Stepp, Mary Ann; Pal-Ghosh, Sonali; Tadvalkar, Gauri et al. (2018) Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res 169:91-98
Pang, Ji-Jie; Yang, Zhuo; Jacoby, Roy A et al. (2018) Cone synapses in mammalian retinal rod bipolar cells. J Comp Neurol 526:1896-1909
Dharmat, Rachayata; Eblimit, Aiden; Robichaux, Michael A et al. (2018) SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. J Cell Biol 217:2851-2865
DuPont, Mariana; Jones, Evan M; Xu, Mingchu et al. (2018) Investigating the disease association of USH2A p.C759F variant by leveraging large retinitis pigmentosa cohort data. Ophthalmic Genet 39:291-292
Barrasso, Anthony P; Tong, Xuefei; Poché, Ross A (2018) The mito::mKate2 mouse: A far-red fluorescent reporter mouse line for tracking mitochondrial dynamics in vivo. Genesis 56:
Xiao, Yangyan; de Paiva, Cintia S; Yu, Zhiyuan et al. (2018) Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol 30:457-470

Showing the most recent 10 out of 349 publications