Abstract

The core facilities will maintain and expand the Vision Research Center established in the Department of Ophthalmology at Washington University to provide essential services for faculty members whose research interests are in one or another aspect of vision. The Vision Research Center significantly facilitates the interaction between several investigators and makes it possible for them to advance their ongoing research, most of which is supported by individual research grants from NEI. The current application requests support for one year for a continuing service module (the electronics and machine shops) and a new EM module. Core grant support for one year only is requested, even though this is the time for our fives years competing renewal application, because the department is in a state of transition with the arrival of Dr. Henry Kaplan, as chairman, in April, 1988. Dramatic expansion of the clinical and research faculty will occur in the next 12 months and the configuration of the Core Grant will be significantly different in June, 1989 from that requested in this application (please see Background for details).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY002687-11
Application #
3102540
Study Section
Vision Research and Training Committee (VSN)
Project Start
1978-12-01
Project End
1990-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Ruzycki, Philip A; Zhang, Xiaodong; Chen, Shiming (2018) CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin 11:42
Brightman, Diana S; Grant, Rachel L; Ruzycki, Philip A et al. (2018) MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep 8:11902
Hamilton, Paul D; Andley, Usha P (2018) In vitro interactions of histones and ?-crystallin. Biochem Biophys Rep 15:7-12
Lin, Jonathan B; Moolani, Harsh V; Sene, Abdoulaye et al. (2018) Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration. JCI Insight 3:
Kraus, Courtney L; Culican, Susan M (2018) New advances in amblyopia therapy II: refractive therapies. Br J Ophthalmol 102:1611-1614
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3:
Lin, Jonathan B; Kubota, Shunsuke; Mostoslavsky, Raul et al. (2018) Role of Sirtuins in Retinal Function Under Basal Conditions. Adv Exp Med Biol 1074:561-567
Vinberg, Frans; Chen, Jeannie; Kefalov, Vladimir J (2018) Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors. Prog Retin Eye Res 67:87-101
Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844
Sato, Shinya; Peshenko, Igor V; Olshevskaya, Elena V et al. (2018) GUCY2D Cone-Rod Dystrophy-6 Is a ""Phototransduction Disease"" Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1. J Neurosci 38:2990-3000

Showing the most recent 10 out of 696 publications