RESEARCH PLAN: COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and functional instruments are used extensively in animal (Drs. Weinreb, Freeman, Yu, La Spada, Zhang, Freeman) and human studies of glaucoma (Drs. Weinreb, Ju, Lindsay, Zangwill, Medeiros, Balasubramanian) and retinal disease (Drs. Freeman, Yu, Bartsch, Zhang, Cheng). The recent development and commercialization of imaging instruments such as SD-OCT has brought a significant improvement in our ability to visualize and measure the retina in-vivo in both animals and humans. These instruments have potential to dramatically improve our ability to understand the histopathology of major eyes diseases including glaucoma, age-related macular degeneration and diabetic retinopathy. These instruments represent a generational leap forward in technological development and several orders of magnitude more data than previous instruments. The challenge facing both ophthalmic clinicians and researchers is how best to utilize the vast quantity of data to 1) enhance our understanding of the histopathology of eye diseases, and 2) identify structural biomarkers of disease and its progression toward the ultimate goal of improving patient management. The computational ophthalmology module will provide essential centralized resources to support the computationally intensive analysis of structural imaging and functional tests used in animal and human vision research studies. This module will provide dedicated computational resources with a capacity to meet high computational demands and software toolkits that leverage these computational resources so that researchers can analyze the complex and data intensive retinal datasets (imaging and functional testing) outside of the proprietary software available with each ophthalmic test.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
4P30EY022589-05
Application #
9087265
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Kabbara, Sami W; Zangwill, Linda M; Mundae, Rusdeep et al. (2018) Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis. Br J Ophthalmol 102:344-351
Biswas, Pooja; Naeem, Muhammad Asif; Ali, Muhammad Hassaan et al. (2018) Whole-Exome Sequencing Identifies Novel Variants that Co-segregates with Autosomal Recessive Retinal Degeneration in a Pakistani Pedigree. Adv Exp Med Biol 1074:219-228
Meshi, Amit; Lin, Tiezhu; Dans, Kunny et al. (2018) COMPARISON OF RETINAL PATHOLOGY VISUALIZATION IN MULTISPECTRAL SCANNING LASER IMAGING. Retina :
Penteado, Rafaella C; Zangwill, Linda M; Daga, Fábio B et al. (2018) Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma. J Glaucoma 27:481-489
Ghahari, Elham; Bowd, Christopher; Zangwill, Linda M et al. (2018) Macular Vessel Density in Glaucomatous Eyes With Focal Lamina Cribrosa Defects. J Glaucoma 27:342-349
Kilic Muftuoglu, Ilkay; Bartsch, Dirk-Uwe; Barteselli, Giulio et al. (2018) VISUALIZATION OF MACULAR PUCKER BY MULTICOLOR SCANNING LASER IMAGING. Retina 38:352-358
Garg, Aakriti; De Moraes, C Gustavo; Cioffi, George A et al. (2018) Baseline 24-2 Central Visual Field Damage Is Predictive of Global Progressive Field Loss. Am J Ophthalmol 187:92-98
Chu, Fang-I; Marín-Franch, Iván; Ramezani, Koosha et al. (2018) Associations between structure and function are different in healthy and glaucomatous eyes. PLoS One 13:e0196814
Mitani, Akinori; Dong, Mingyuan; Komiyama, Takaki (2018) Brain-Computer Interface with Inhibitory Neurons Reveals Subtype-Specific Strategies. Curr Biol 28:77-83.e4
Yarmohammadi, Adeleh; Zangwill, Linda M; Manalastas, Patricia Isabel C et al. (2018) Peripapillary and Macular Vessel Density in Patients with Primary Open-Angle Glaucoma and Unilateral Visual Field Loss. Ophthalmology 125:578-587

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