A. INTRODUCTIONAs required by this RFA, the proposed Fragile X Research Center grant is submitted as a supplement to theP30 Mental Retardation and Developmental Disabilities Research Center at the University of North Carolina atChapel Hill, Joe Piven, MD, Principal Investigator. Also as required, a separate administrative core is proposedin support of the Fragile X Center grant. Dr. Don Bailey will serve as the Fragile X Center Director, AssociateDirector of Fragile X Research for the North Carolina MRDDRC, and Director of the Administrative Core. Dr.Debra Skinner will serve as Associate Director of the Administrative Core. Dr. Bailey has been the Fragile XCenter director on our current Fragile X Center and Dr. Skinner has been an investigator affiliated with thecenter and co-director of the current center's Data Collection Core. The Administrative Core will manage thedaily operations of the Fragile X Center, facilitate linkages and integration across projects, and coordinatecommunications with the NICHD and with the other funded Fragile X Centers. The core will also ensure thatthe aims of the research projects are carried out by the research project leaders and that support cores providethe necessary services to further the research aims. To accomplish these aims, the core will be responsible forfive major activities.
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