Cardiovascular disease is a leading cause of morbidity and mortality, accounting for upwards of 900,000 deaths annually in our country and many millions more worldwide. NYU School of Medicine has identified improved cardiovascular health as one of its key strategic priorities for the next decade. Toward that end, the School of Medicine is Investing in faculty, facilities and infrastructure enhancements to support the continued growth of a world-class program in cardiovascular research, education, and patient care. As part of the NIH NHLBI ARRA/P30 mechanism, this application requests support for a start-up package to hire a Newly-Independent Investigator who will join our Division of Cardiology (Core Center) and the Cardiovascular Research Center. Following a national search, we have identified an extraordinarily promising newly-independent investigator poised to make Important contributions to cardiovascular health through fundamental and translational research in an area of great relevance to the NHLBI - vascular biology and disease. The new investigator will receive a tenure-track appointment in the Departments of Medicine and Cell Biology, and join our Sackler Graduate Program in Biological Sciences. He will join a vibrant research environment within the Division of Cardiology and the broader NYU community, with expertise that ranges from fundamental laboratory-based studies to patient-oriented clinical research. He will be provided with a generous start-up package designed to assure his success as a newly-independent investigator and support his evolution into a productive established investigator, including salary, programmatic and pilot project support for a period of no less than four years. Finally, the newly-independent investigator will benefit from a highly interactive and nurturing environment, with formal mentoring provided by senior investigators with a strong track-record of successful career development and collaboration. The recruitment of this new investigator will most certainly """"""""contribute to the building of a community of multidisciplinary researchers focusing on areas of biomedical research that are relevant"""""""" to the mission of the NHLBI.

Public Health Relevance

The clinical manifestations of vascular disease, including Ml, stroke and peripheral vascular disease, are responsible for enormous morbidity and mortality in the US. The newly-independent investigator we have identified is establishing a vibrant program exploring vascular disease pathogenesis. Insights from these studies have the potential to improve cardiovascular health, and therefore are of great biomedical relevance

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Center Core Grants (P30)
Project #
5P30HL101270-02
Application #
7937873
Study Section
Special Emphasis Panel (ZHL1-CSR-E (O1))
Program Officer
Carlson, Drew E
Project Start
2009-09-30
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$767,875
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Rayner, K J; Fernandez-Hernando, C; Moore, K J (2012) MicroRNAs regulating lipid metabolism in atherogenesis. Thromb Haemost 107:642-7
Chamorro-Jorganes, Aranzazu; Araldi, Elisa; Penalva, Luiz O F et al. (2011) MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol 31:2595-606
Davalos, Alberto; Goedeke, Leigh; Smibert, Peter et al. (2011) miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci U S A 108:9232-7
Moore, Kathryn J; Rayner, Katey J; Suarez, Yajaira et al. (2011) The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr 31:49-63
Rayner, Katey J; Esau, Christine C; Hussain, Farah N et al. (2011) Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 478:404-7
Fernández-Hernando, Carlos; Suárez, Yajaira; Rayner, Katey J et al. (2011) MicroRNAs in lipid metabolism. Curr Opin Lipidol 22:86-92
Rayner, Katey J; Suárez, Yajaira; Dávalos, Alberto et al. (2010) MiR-33 contributes to the regulation of cholesterol homeostasis. Science 328:1570-3
Moore, Kathryn J; Rayner, Katey J; Suarez, Yajaira et al. (2010) microRNAs and cholesterol metabolism. Trends Endocrinol Metab 21:699-706