Lung disease is a significant cause of morbidity and mortality in the United States. While all other major causes of death are decreasing, age-adjusted mortality due to lung disease continues to rise. The overall purpose of this COBRE Phase III renewal application is to continue the development of the research program in Lung Biology and Disease at The Vermont Lung Center (VLC) of the University of Vermont College of Medicine. The keystone of the VLC program is excellence. The scientific strengths include airway epithelial cell biology, cystic fibrosis, asthma inflammation, lung physiology, translational animal studies, and clinical investigation into the pathogenesis of lung disease. In the last funding cycle e we have continued to amass a record of productivity including: recruitment of a critical mass of well trained PhD and MD pulmonary scientists, high-impact peer-reviewed publications and continued as well as considerable increase in extramural funding. A critical requirement for the continued success of the Vermont Lung Center is the stimulating environment in which optimal career development can occur. The current goals of the VLC-COBRE are therefore to: 1) Develop the careers of a group of talented MD and PhD biomedical investigators 2) Provide skilled mentoring and consultation on competitive scientific approaches 3) Maintain a """"""""cutting edge"""""""" research milieu 4) Develop a clinical studies core, maintain transgenic/knockout animal and small animal phenotyping core, This proposed program will build towards sustainability of the VLC by forming the nexus from which center grant applications will be created. This proposal also addresses the urgent need to expand and support translational multidisciplinary research at UVM, because this is how advances in basic molecular, cellular and genetic science are converted into new methods of diagnosis and therapy.
(provided by applicant): Lung disease represents a huge burden on society in terms of death and disease. The purpose of this proposal is to further the development of the Vermont Lung Center that supports research into lung biology and disease.
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| Dixon, Anne E; Gerald, Lynn B (2015) Promoting weight loss in asthma. Respirology 20:179-80 |
| Kapadia, S G; Wei, C; Bartlett, S J et al. (2014) Obesity and symptoms of depression contribute independently to the poor asthma control of obesity. Respir Med 108:1100-7 |
| van der Vliet, Albert; Janssen-Heininger, Yvonne M W (2014) Hydrogen peroxide as a damage signal in tissue injury and inflammation: murderer, mediator, or messenger? J Cell Biochem 115:427-35 |
| Sideleva, O; Dixon, A E (2014) The many faces of asthma in obesity. J Cell Biochem 115:421-6 |
| Hoffman, Sidra M; Tully, Jane E; Nolin, James D et al. (2013) Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis. Respir Res 14:141 |
| Hobson, Julia; Gummadidala, Phani; Silverstrim, Brian et al. (2013) Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis. Breast Cancer Res Treat 139:391-401 |
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| Anathy, Vikas; Roberson, Elle; Cunniff, Brian et al. (2012) Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis. Mol Cell Biol 32:3464-78 |
| Dixon, Anne (2012) The treatment of asthma in obesity. Expert Rev Respir Med 6:331-40 |
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