Transgenic Mice with Altered Calcium Handling

Kranias, Evangelia G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
• Project #: 1P40RR012358-01
• Application #: 2380050
• Study Section: National Center for Research Resources Initial Review Group (RIRG)
• Project Start: 1997-08-01
• Project End: 2002-07-31
• Budget Start: 1997-08-01
• Budget End: 1998-07-31
• Support Year: 1
• Fiscal Year: 1997

Institution

• Name: University of Cincinnati
• Department: Pharmacology
• Type: Schools of Medicine
• City: Cincinnati
• State: OH
• Country: United States
• Zip Code: 45221

Publications

Zhao, Wen; Frank, Konrad F; Chu, Guoxiang et al. (2003) Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state. Cardiovasc Res 57:71-81

Dash, Rajesh; Schmidt, Albrecht G; Pathak, Anand et al. (2003) Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Cardiovasc Res 57:704-14

Sato, Yoji; Schmidt, Albrecht G; Kiriazis, Helen et al. (2003) Compensated hypertrophy of cardiac ventricles in aged transgenic FVB/N mice overexpressing calsequestrin. Mol Cell Biochem 242:19-25

Said, M; Vittone, L; Mundina-Weilenmann, C et al. (2003) Role of dual-site phospholamban phosphorylation in the stunned heart: insights from phospholamban site-specific mutants. Am J Physiol Heart Circ Physiol 285:H1198-205

Song, Qiujing; Schmidt, Albrecht G; Hahn, Harvey S et al. (2003) Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J Clin Invest 111:859-67

Champion, Hunter C; Georgakopoulos, Dimitrios; Haldar, Saptarsi et al. (2003) Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation 108:2790-7

Brittsan, Angela G; Ginsburg, Kenneth S; Chu, Guoxiang et al. (2003) Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circ Res 92:769-76

Cross, Heather R; Kranias, Evangelia G; Murphy, Elizabeth et al. (2003) Ablation of PLB exacerbates ischemic injury to a lesser extent in female than male mice: protective role of NO. Am J Physiol Heart Circ Physiol 284:H683-90

Schmidt, Albrecht G; Zhai, Jing; Carr, Andrew N et al. (2002) Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure. Cardiovasc Res 56:248-59

Chu, Guoxiang; Kranias, Evangelia G (2002) Functional interplay between dual site phospholambam phosphorylation: insights from genetically altered mouse models. Basic Res Cardiol 97 Suppl 1:I43-8