Copper pyruvaldehyde bis(N4-methyl-thiosemicarbazonato), CuPTSM, potentially can be labeled with copper radioisotopes. The labeled CuPTSM is attractive to use in positron emission tomography as a radiotracer. While results obtained from animal studies are promising, problems have been encountered in human studies. Our previous ESR studies have shown that CuPTSM is more strongly bound to human serum albumin (HSA) than to dog serum albumin (DSA). We attempted to determine the transport of CuPTSM from HSA to liposomes. The results indicated that about 70% of the CuPTSM can be transferred into liposome from HSA. CuPTSM has faster motion in liposomes than in HSA.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001008-21
Application #
5222095
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
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Sheng, Zhi-Guo; Huang, Wei; Liu, Yu-Xiang et al. (2013) Ofloxacin induces apoptosis via ?1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes. Toxicol Appl Pharmacol 267:74-87
Sheng, Zhi-Guo; Huang, Wei; Liu, Yu-Xiang et al. (2013) Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression. Toxicol Appl Pharmacol 267:88-94
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