Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI026804-03
Application #
3454804
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1989-04-01
Project End
1991-07-31
Budget Start
1991-04-01
Budget End
1991-07-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Cadavid, D; Thomas, D D; Crawley, R et al. (1994) Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis. J Exp Med 179:631-42
Thomas, D D; Cadavid, D; Barbour, A G (1994) Differential association of Borrelia species with cultured neural cells. J Infect Dis 169:445-8
Shoberg, R J; Jonsson, M; Sadziene, A et al. (1994) Identification of a highly cross-reactive outer surface protein B epitope among diverse geographic isolates of Borrelia spp. causing Lyme disease. J Clin Microbiol 32:489-500
Sadziene, A; Barbour, A G; Rosa, P A et al. (1993) An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo. Infect Immun 61:3590-6
Comstock, L E; Fikrig, E; Shoberg, R J et al. (1993) A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells. Infect Immun 61:423-31
Shoberg, R J; Thomas, D D (1993) Specific adherence of Borrelia burgdorferi extracellular vesicles to human endothelial cells in culture. Infect Immun 61:3892-900
Comstock, L E; Thomas, D D (1991) Characterization of Borrelia burgdorferi invasion of cultured endothelial cells. Microb Pathog 10:137-48
Riviere, G R; Weisz, K S; Adams, D F et al. (1991) Pathogen-related oral spirochetes from dental plaque are invasive. Infect Immun 59:3377-80
Sadziene, A; Thomas, D D; Bundoc, V G et al. (1991) A flagella-less mutant of Borrelia burgdorferi. Structural, molecular, and in vitro functional characterization. J Clin Invest 88:82-92