This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our laboratory has been studying the structure and targeting capacity of various chromodomains. These domains appear in many proteins that interact with chromatin and are believed to either bind a methyllysine-containing peptide or a nucleic acid sequence in order to regulate gene expression. We have previously published the structures of complexes of chromodomains from HP1 and Pc proteins as bound to distinct lysine-methylated histone H3 peptides. Triple resonance data needs to be collected to delineate the 3D structure of two chromodomains isolated from two distinct proteins involved in eukaryotic gene regulation. In addition data will be collected to determine the backbone dynamics of these chromodomains.
Showing the most recent 10 out of 613 publications