The Alzheimer's Disease Research Center (ADRC) at Columbia University was established to courage and integrate research on the causes of Alzheimer's Disease (AD) and related age-related neurodegenerative diseases and to foster the development of improved diagnosis, prevention and treatment of these conditions. The Clinical Core and Neuropathology Core of the ADRC provide the patient and tissue resources for the examination of new diagnostic and treatment modalities and for biological investigation. The population of the Clinical Core is ethnically diverse with substantial numbers of White, Black and Hispanic patients. The integral research projects of the ADRC are focused on the molecular biology of dementia and on early changes in brain function in AD. These research projects are extended by a large number of independently funded projects on the dementias and their underlying biology which have been nucleated by the Center and draw on ADRC resources. The ADRC actively encourages research in all aspects of AD including caregiving, treatment and biology. The ADRC also serves and a source of education and information on AD. Through the efforts of Education and Information Transfer ore we provide a Web Page with both local and general information; training programs in the biology and psychology of aging; and extensive seminar and works- in-progress series; education for primary care physicians in care of AD patients and educational programs to the lay community. The ADRC offers research services for genotyping, DNA storage, cell line production and DNA sequencing and maintains a bank of appropriate tissues, DNA and cell lines to facilitate research in this and other research centers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG008702-15
Application #
6757850
Study Section
Special Emphasis Panel (ZAG1-PKN-7 (J1))
Program Officer
Phelps, Creighton H
Project Start
1989-09-29
Project End
2005-05-31
Budget Start
2004-07-01
Budget End
2005-05-31
Support Year
15
Fiscal Year
2004
Total Cost
$1,998,505
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pathology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Bravo, Francisca Vaz; Da Silva, Jorge; Chan, Robin Barry et al. (2018) Phospholipase D functional ablation has a protective effect in an Alzheimer's disease Caenorhabditis elegans model. Sci Rep 8:3540
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Grivel, Margaux M; Leong, Wei; Masucci, Michael D et al. (2018) Impact of lifetime traumatic experiences on suicidality and likelihood of conversion in a cohort of individuals at clinical high-risk for psychosis. Schizophr Res 195:549-553
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169

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