This project will develop potential PET ligands for each of the three opioid receptors (the promising compounds will be radiolabeled and evaluated further in Project 1b). Both agonists and antagonists will be synthesized. A potential ligand will also be made for the ORL-1 receptor. Secondary objectives involve further synthetic research on buprenorphine-like compounds and synthesis of compounds for the Center group for primate studies that are unavailable or prohibitively expensive.
| Moses, Tabitha E H; Lundahl, Leslie H; Greenwald, Mark K (2018) Factors associated with sedative use and misuse among heroin users. Drug Alcohol Depend 185:10-16 |
| Reilly, Mark P; Berndt, Sonja I; Woods, James H (2016) On the nature of directed behavior to drug-associated light cues in rhesus monkeys (Macaca mulatta). Behav Anal (Wash D C) 16:200-209 |
| Woodcock, Eric A; Lundahl, Leslie H; Stoltman, Jonathan J K et al. (2015) Progression to regular heroin use: examination of patterns, predictors, and consequences. Addict Behav 45:287-93 |
| Stoltman, Jonathan J K; Woodcock, Eric A; Lister, Jamey J et al. (2015) Heroin delay discounting: Modulation by pharmacological state, drug-use impulsivity, and intelligence. Exp Clin Psychopharmacol 23:455-63 |
| Stoltman, Jonathan J K; Woodcock, Eric A; Lister, Jamey J et al. (2015) Exploration of the telescoping effect among not-in-treatment, intensive heroin-using research volunteers. Drug Alcohol Depend 148:217-20 |
| Mancha, Brent Edward; Hulbert, Alicia; Latimer, William W (2012) A latent class analysis of alcohol abuse and dependence symptoms among Puerto Rican youth. Subst Use Misuse 47:429-41 |
| Moynihan, Humphrey A; Derrick, Ian; Broadbear, Jillian H et al. (2012) Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible ? opioid receptor antagonist effects. J Med Chem 55:9868-74 |
| Mancha, Brent E; Rojas, Vanessa C; Latimer, William W (2012) Alcohol use, alcohol problems, and problem behavior engagement among students at two schools in northern Mexico. Alcohol 46:695-701 |
| Pichika, Rama; Jewett, Douglas M; Sherman, Philip S et al. (2010) Synthesis and in vivo brain distribution of carbon-11-labeled ?-opioid receptor agonists. Nucl Med Biol 37:989-96 |
| Cooper, Ziva D; Shi, Yong-Gong; Woods, James H (2010) Reinforcer-dependent enhancement of operant responding in opioid-withdrawn rats. Psychopharmacology (Berl) 212:369-78 |
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