The Core provides the mechanism for integrating and coordinating the interdisciplinary approaches to drugabuse research at Virginia Commonwealth University (VCU). It provides shared resources and serves toFacilitate communication among all investigators in the Center. Moreover, the Core is available to all drugabuse researchers at VCU. It serves as a mechanism for fostering interactions among the participants in theCenter and those who are supported by other NIDA grants. The Core consists of four components. TheAdministrative Component is responsible for scheduling drug abuse seminars, attending to travel for invitedspeakers, organizing regular meetings for participating faculty, coordinating scientific exchange, distributionof drugs to collaborators, and fostering training. The Mass Spectrometry Component provides qualitativeand quantitative sample analysis that is essential for many of the drug abuse research projects at theUniversity. The Small Grants Program will support two VCU faculty members yearly. The goals are to fundpromising young investigators who demonstrate potential for independent research, to attract seniorscientists from other fields into drug abuse research, and to foster new collaborations. Past awardees havesubsequently been very successful in obtaining their own individual funding as a result of the Small GrantsProgram. The Mouse 'Knock-out Facility' provides genetically modified mice to investigators working incannabinoid, opioid, and nicotine areas. The facility will allow sufficient breeding so that adequate numbersof animals will be available. A major advantage of a Center Core is that it provides shared resources thatare more economical and that are sometimes not available unless they are funded by this type mechanism.Of course, the Core also affords the opportunity for researchers from many different disciplines to becomefamiliar with areas of research that will complement their own endeavors. It is also through the Core that weare able to be a national resource.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA005274-19A1
Application #
7318577
Study Section
Special Emphasis Panel (ZDA1-RXL-E (02))
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
19
Fiscal Year
2007
Total Cost
$287,941
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Bagdas, Deniz; Alkhlaif, Yasmin; Jackson, Asti et al. (2018) New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice. Neuropharmacology 138:72-79
Jackson, Kia J; Muldoon, Pretal P; Walters, Carrie et al. (2016) Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behav Pharmacol 27:50-6
Nass, Sara R; Long, Jonathan Z; Schlosburg, Joel E et al. (2015) Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge. J Neuroimmune Pharmacol 10:364-70
Muldoon, P P; Chen, J; Harenza, J L et al. (2015) Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. Br J Pharmacol 172:869-82
Poklis, Justin L; Devers, Kelly G; Arbefeville, Elise F et al. (2014) Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death. Forensic Sci Int 234:e14-20
Poklis, Justin L; Nanco, Carol R; Troendle, Michelle M et al. (2014) Determination of 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe) in serum and urine by high performance liquid chromatography with tandem mass spectrometry in a case of severe intoxication. Drug Test Anal 6:764-9
Ignatowska-Jankowska, B M; Ghosh, S; Crowe, M S et al. (2014) In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol 171:1392-407
Bagdas, Deniz; Muldoon, Pretal P; Zhu, Andy Z X et al. (2014) Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. Neuropharmacology 85:67-72
Wolf, Carl E; Goldstein, Ashley; Poklis, Justin L et al. (2014) Evaluation of an enzyme immunoassay for the detection of methadone metabolite EDDP [2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine] in urine. J Clin Lab Anal 28:136-40
Burston, James J; Sagar, Devi Rani; Shao, Pin et al. (2013) Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. PLoS One 8:e80440

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