This project proposes to define the effects of organ preservation protocols involving high dose radiotherapy (5000+ cGy) with or without chemotherapy on tongue strength and swallowing function in 50 oral tongue and tongue base cancer patients with previously untreated Stages II to IV disease, and to measure the effectiveness of swallow maneuvers in improving the swallow. Each patient will be followed for 12 months after treatment completion. All patients will be studied pretreatment, and at 1 month, 3 months, 6 months and 12 months post completion of chemoradiotherapy. At each of these data collection points, each patient will receive a videofluoroscopic assessment of swallowing and an assessment of tongue strength. The radiographic studies of swallowing will be analyzed in detail for the physiologic swallowing disorders present, and the temporal and biomechanical characteristics of the swallow. Each patient's response to swallow maneuvers will be defined.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE011921-05
Application #
6354657
Study Section
Project Start
1996-09-30
Project End
2001-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2000
Total Cost
$112,804
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
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