This Core resource will provide comprehensive biostatistics and bioinformatics consultation and collaborationto all projects in the proposed Johns Hopkins Head and Neck SPORE. In addition, it will provide support fordata storage, informatics, and computing, and assist with the identification and solution of complex datatasks arising in the course of project activities. Core members will work with project investigators across awide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives,availability of public-access genomic information, and data storage), statistical quality control (includingartifact detection and preprocessing of data from genomic technologies), data analysis (includingvisualization, biostatistical modeling, and assistance with manuscript writing), and development of innovativecustomized biostatistics and bioinformatics methodologies and tools if required by specific projects. Theproposed Head and Neck SPORE Biostatistics Core will be housed in the Division of Clinical Trials andBiometry of the Department of Oncology, an active and committed group of biostatistics and bioinformaticsfaculty members, with access to state-of-the art equipment and a broad range of expertise. This Coreresource is the continuation of an existing resource within the original and current Head and Neck SPOREprogram at Johns Hopkins. Core members have a strong commitment to this SPORE, stemming from: a) ahistory of collaboration with the investigators of this as well as other SPORE projects, b) an active andindependently funded agenda of synergistic projects, and c) a demonstrated interest and understanding ofboth the biological and analytical questions and challenges. All proposed projects are anticipated to makeuse of this resource.
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