The Morphology and Clinical Applications Core is a critical component of our Center activities. We are concerned with determining the relevance of our data to human disease, and are particularly interested in the significance of the biologic phenomena studied when viewed against the background of what is known of the natural history of human disease. The opportunity to use a human tissue bank to make crosscorrelations between projects is also particularly important. For example, one would like to correlate the upregulated expression of specific mediator molecules such as osteopontin with evidence of endothelial activation or smooth muscle phenotypic changes within abnormal renal blood vessels or to correlate increased expression of SPARC with resolution of proliferative glomerular lesions. The identification of the various mediator molecules in human development may allow us to identify mechanisms which normally control the expression of such molecules. The Core is therefore intended to provide tissue, technical and intellectual support for the projects, but in turn is designed to extend and amplify the work of the individual projects in order to better understand human renal disease as mandated by the Center grant program.
| Liu, Gang; Changsirikulchai, Siribha; Hudkins, Kelly L et al. (2008) Identification of platelet-derived growth factor D in human chronic allograft nephropathy. Hum Pathol 39:393-402 |
| Petermann, Arndt T; Pippin, Jeffrey; Durvasula, Raghu et al. (2005) Mechanical stretch induces podocyte hypertrophy in vitro. Kidney Int 67:157-66 |
| Vaughan, Michael R; Pippin, Jeffrey W; Griffin, Sian V et al. (2005) ATRA induces podocyte differentiation and alters nephrin and podocin expression in vitro and in vivo. Kidney Int 68:133-44 |
| Griffin, Sian V; Krofft, Ronald D; Pippin, Jeffrey W et al. (2005) Limitation of podocyte proliferation improves renal function in experimental crescentic glomerulonephritis. Kidney Int 67:977-86 |
| Durvasula, Raghu V; Petermann, Arndt T; Hiromura, Keiju et al. (2004) Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 65:30-9 |
| Hudkins, Kelly L; Gilbertson, Debra G; Carling, Matthew et al. (2004) Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy. J Am Soc Nephrol 15:286-98 |
| Francki, Aleksandar; McClure, Timothy D; Brekken, Rolf A et al. (2004) SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells. J Cell Biochem 91:915-25 |
| Petermann, Arndt; Hiromura, Keiju; Pippin, Jeffrey et al. (2004) Differential expression of d-type cyclins in podocytes in vitro and in vivo. Am J Pathol 164:1417-24 |
| Petermann, Arndt T; Pippin, Jeffrey; Krofft, Ron et al. (2004) Viable podocytes detach in experimental diabetic nephropathy: potential mechanism underlying glomerulosclerosis. Nephron Exp Nephrol 98:e114-23 |
| Rodriguez-Iturbe, Bernardo; Vaziri, Nosratola D; Herrera-Acosta, Jaime et al. (2004) Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all. Am J Physiol Renal Physiol 286:F606-16 |
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