Management PlanWe will implement the following procedures to coordinate the collaborations in this proposal and to monitor theprogress of the individual group. Many of these actions are already in existence and have helped to promotethe cohesiveness of the research activities at the Center as documented in the reports of our external advisoryboard, which are attached as Appendix 1.1. Fellows and their lab members present their work at the weekly group meeting. Each fellow laboratorypresents every two months ensuring regular feedback from the group.2. Andrew Murray meets weekly with one fellow on a rotating basis. This one-on-one discussion ensuresconsistent and regular mentoring.3. Each fellow chooses a mentoring committee with advice from Murray and Stern. The committee iscomposed of three faculty members and meets every year to discuss the fellow's goals, progress, and futureresearch and career plans (committees are listed in Appendix 5). Stern attends each of these meetings,prepares a summary of the committee's observations and recommendations and discusses possible actionswith the fellow.4. We will assemble an External Advisory Board to provide guidance on the success of the fellows programand the performance of the NIGMS funded projects. We will also seek guidance from the Board on ouroutreach and education efforts and on the goal to coordinate Systems Biology activities with the Department ofSystems Biology at the Medical School. We had an excellent experience with the External Advisory Boardchosen to supervise our first Center grant period. The board's outside perspective provided critical feedback onthe progress of the research projects, the trajectory of individual fellows, and the fellows program in general.5. The non-Harvard project leaders (Elowitz and Barkai) have committed to spend at least a week per year atthe FAS Center for Systems Biology. Even such short periods have proven effective in the past in creating aspecial connection between Barkai and Elowitz on the one hand and Center researchers on the other. Barkaiand Elowitz have invigorated many research projects at the Center with their insightful advice. Over the last 2months, Barkai has spent a 9 month sabbatical and made a 1 month summer visit to the Center, and we areenthusiastic about repeating the latter on an annual basis.6. Center website: we have created a CMB website which includes a description of projects and participatingscientists, CMB publications and oversight. Most importantly, the website provides free access to all resourcescreated by CMB projects (see below in progress report). We will upgrade the website to include the newprojects, people and resources from this proposal. In addition, we will add a new feature describing andadvertising the joint activities of the Boston-wide systems biology initiative CSB2 (see below), and jointactivities with other NIGMS funded National Centers for Systems Biology.7. We will continue to hold regular meetings of all the Harvard Pis associated with the grant. These will occurmonthly and will be supplemented by two otheractivities: a weekly Friday afternoon talk given by a member ofthe Harvard systems biology community, which is hosted by the FAS Center for Systems Biology, and amonthly student/faculty talk hosted by the Harvard-wide Systems Biology graduate program. All the HarvardbasedPis will attend these talks.8. We will organize an annual 2-3 day retreat for all researchers on the grant. We will invite the HarvardSystems Biology community plus interested faculty from Harvard and Boston area Systems Biology Centers aspart of the Council on Systems Biology in Boston initiative (see below). The format of past retreats - eachspeaker introduces a project in need of input/collaboration from another discipline - was well received andhelped to create new connections between researchers from different backgrounds. We will therefore build onthis successful format.
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