The proposed SCOR program will focus on the etiology and pathophysiology of hyaline membrane disease (HMD), with the ultimate aim of improved treatment and prevention. The investigators have produced a homologue of HMD in the prematurely delivered monkey (M. nemestrina). This model provides a unique opportunity to obtain precise information about sequential pathophysiological and biochemical changes occurring throughout the course and reparitive processes of HMD. Specific projects will focus on sequential changes occurring in the lung, including mechanical properties, gas exchange, quantitative and qualitative estimates of surface-active lipoproteins, and ultrastructure. Other projects related to pathogenesis include studies of synthesis, storage, and turnover of surface active pulmonary lipoproteins in the mutant-beige mouse, and studies on the development of ventilatory control in relation to maturation of the central nervous system in the newborn monkey. Specific treatment and prevention of HMD is lacking and will require increased knowledge of pathogenesis. In the interim, there is need for improvements in supportive therapy. Several projects are directed at improved monitoring (ultrasonic detection of pneumothorax, continuous transcutaneous PO2 electrodes) and treatment (early intervention with distending airway pressure). Long term consequences of HMD and current methods of intervention and treatment will also be examined. An evaluation of survivors of HMD and low birthweight will be conducted by a multidisciplinary child development team to determine the effects on neurological, emotional and mental development.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL019187-09
Application #
3106579
Study Section
(SRC)
Project Start
1976-06-30
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Zumpano, Michael P; Richtsmeier, Joan T (2003) Growth-related shape changes in the fetal craniofacial complex of humans (Homo sapiens) and pigtailed macaques (Macaca nemestrina): a 3D-CT comparative analysis. Am J Phys Anthropol 120:339-51
Zumpano, Michael P (2002) Size and shape changes during late fetal growth (137-157 gestational days) in the pigtailed macaque (Macaca nemestrina) craniofacial complex: an application using three-dimensional coordinate data and finite element scaling analysis. Anat Rec 267:307-20
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Juul, S E; Kinsella, M G; Truog, W E et al. (1996) Lung hyaluronan decreases during group B streptococcal pneumonia in neonatal piglets. Am J Respir Crit Care Med 153:1567-70
Truog, W E; Gibson Jr, R L; Henderson, W R et al. (1990) Tumor necrosis factor-induced neonatal pulmonary hypertension: effects of dazmegrel pretreatment. Pediatr Res 27:466-71
LaFramboise, W A; Standaert, T A; Milley, J R et al. (1990) Developmental changes in the response of the newborn to sustained ventilatory elastic loads. Am Rev Respir Dis 141:752-7
Redding, G J; Gibson, R L; Standaert, T A et al. (1990) Regional pulmonary blood flow in piglets during group B streptococcal bacteremia. Am Rev Respir Dis 141:1209-13
Jackson, J C; Palmer, S; Wilson, C B et al. (1988) Postnatal changes in lung phospholipids and alveolar macrophages in term newborn monkeys. Respir Physiol 73:289-300
Watchko, J F; Standaert, T A; Mayock, D E et al. (1988) Ventilatory failure during loaded breathing: the role of central neural drive. J Appl Physiol 65:249-55
Truog, W E; Gibson, R L; Juul, S E et al. (1988) Neonatal group B streptococcal sepsis: effects of late treatment with dazmegrel. Pediatr Res 23:352-6

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