Abstract

The major goal of this project is to use information about hypertension in mice to generate testable hypotheses about hypertension in the human populations gathered by Project I in this Specialized Center of Research (SCOR). Specifically, we expect that (a) the quantitative trait loci (QTL) that we generate using the mouse model will predict chromosomal regions to test in humans, (b) the gene interactions we find in the mouse will predict gene interactions to test in humans, and (c) the candidate genes we find by expression or sequence differences will predict candidate genes to test in humans. To find the full range of possible blood pressure genes in the mouse model, we will carry out five additional QTL crosses using genetically diverse mouse strains. Using a combination of techniques, we will narrow the QTL regions focusing on those QTL found on mouse Chr 1, 11, and 18, which are homologous to human hypertension QTL that the focus of Project 1. In addition, we will test candidate genes for expression and sequence differences. By year 3 of the grant, we should have available microarrays with a high proportion of mouse genes, and we will use these in the search for expression differences in candidate genes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL055001-06
Application #
6416269
Study Section
Project Start
2001-02-05
Project End
2002-01-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Duka, Arvi; Schwartz, Faina; Duka, Irena et al. (2006) A novel gene (Cmya3) induced in the heart by angiotensin II-dependent but not salt-dependent hypertension in mice. Am J Hypertens 19:275-81
Shenouda, Sherene M; Johns, Conrado; Kintsurashvili, Ekaterina et al. (2006) Long-term inhibition of the central alpha(2B)-adrenergic receptor gene via recombinant AAV-delivered antisense in hypertensive rats. Am J Hypertens 19:1135-43
Cardoso de Carvalho, Fabio; Bregagnollo, Edson; Santos Silva, Vanessa et al. (2006) Frequency of coronary artery disease in patients with renal artery stenosis without clinical manifestations of coronary insufficiency. Am J Hypertens 19:1125-8
Cui, Jing; Melista, Efthymia; Chazaro, Irmarie et al. (2005) Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. J Hypertens 23:55-62
Manolis, Athanasios J; Iraklianou, Stella; Pittaras, Andreas et al. (2005) Arterial compliance changes in diabetic normotensive patients after angiotensin-converting enzyme inhibition therapy. Am J Hypertens 18:18-22
Ignjacev-Lazich, Ivana; Kintsurashvili, Ekaterina; Johns, Conrado et al. (2005) Angiotensin-converting enzyme regulates bradykinin receptor gene expression. Am J Physiol Heart Circ Physiol 289:H1814-20
Russo, Christopher J; Melista, Efthymia; Cui, Jing et al. (2005) Association of NEDD4L ubiquitin ligase with essential hypertension. Hypertension 46:488-91
Schwartz, Faina; Duka, Arvi; Duka, Irena et al. (2004) Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression. Am J Physiol Heart Circ Physiol 287:H1957-66
Elijovich, Fernando; Laffer, Cheryl L; Schiffrin, Ernesto L et al. (2004) Endothelin-aldosterone interaction and proteinuria in low-renin hypertension. J Hypertens 22:573-82
Erlich, Porat M; Cui, Jing; Chazaro, Irmarie et al. (2003) Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension 41:1191-5

Showing the most recent 10 out of 37 publications