The overall purpose of the Clinical Core B is to provide essential services which will promote and supplement the clinical and basic science projects in ways that would otherwise be prohibitive to the work loads in those individuals sections. In order to perform these functions our aims are to: 1. Provide a centralized human clinical studies facility for study design, patient recruitment, data entry, statistics and scientific oversight for the proposed clinical studies in Projects 1&2; 2. Provide a centralized laboratory facility for oversight of measurements of sequential blood and initial BAL lysyl oxidase and pro-collagen peptide levels and of sequential urine collagen and elastin degradation products for Projects 1&2; 3. Maintain, catalog, organize and provide a centralized tissue pathology service for immunohistochemistry and in situ hybridization on archival open lung biopsy materials for Projects l,2&3; 4. Provide a centralized tissue pathology service for immunohistochemistry and in situ hybridization for processing, storage and staining of fresh human and animal (for Animal Core C) biopsy materials for Projects 1&2.
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| Bandeira-Melo, Christianne; Weller, Peter F (2005) Mechanisms of eosinophil cytokine release. Mem Inst Oswaldo Cruz 100 Suppl 1:73-81 |
| Segel, Michael J; Izbicki, Gabriel; Cohen, Pazit Y et al. (2003) Role of interferon-gamma in the evolution of murine bleomycin lung fibrosis. Am J Physiol Lung Cell Mol Physiol 285:L1255-62 |
| Lucey, Edgar C; Goldstein, Ronald H; Breuer, Raphael et al. (2003) Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysema. Respiration 70:200-5 |
| Subramaniam, Meera; Sugiyama, Kumiya; Coy, David H et al. (2003) Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? Am J Respir Crit Care Med 168:601-11 |
| Izbicki, Gabriel; Or, Reuven; Christensen, Thomas G et al. (2002) Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice. Am J Physiol Lung Cell Mol Physiol 283:L1110-6 |
| Bandeira-Melo, Christianne; Hall, John C; Penrose, John F et al. (2002) Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. J Allergy Clin Immunol 109:975-9 |
| Segel, M J; Or, R; Tzurel, A et al. (2001) All-trans-retinoic acid (ATRA) is of no benefit in bleomycin-induced lung injury. Pulm Pharmacol Ther 14:403-7 |
| O'Regan, A W; Hayden, J M; Body, S et al. (2001) Abnormal pulmonary granuloma formation in osteopontin-deficient mice. Am J Respir Crit Care Med 164:2243-7 |
| Berkman, N; Kremer, S; Or, R et al. (2001) Human recombinant interferon-alpha2a and interferon-alphaA/D have different effects on bleomycin-induced lung injury. Respiration 68:169-77 |
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